| Official Name: | Ruffin, South Carolina |
| Pushpin Map: | South Carolina#USA |
| Pushpin Label: | Ruffin |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | South Carolina |
| Subdivision Type2: | County |
| Subdivision Name2: | Colleton |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 72 |
| Coordinates: | 33.0047°N -80.8156°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 29475 |
| Area Code: | 843, 854 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 1231754 |
Ruffin is an unincorporated community in Colleton County, South Carolina, United States. The community is located on U.S. Route 21, northwest of Walterboro. Ruffin has a post office with ZIP code 29475, which opened on October 19, 1893.[1] [2]