| Ruff Creek | |
| Name Other: | Tributary to South Fork Tenmile Creek |
| Map Size: | 300 |
| Pushpin Map: | USA Pennsylvania#USA |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of Ruff Creek mouth |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States of America |
| Subdivision Type2: | State |
| Subdivision Name2: | Pennsylvania |
| Subdivision Type3: | County |
| Subdivision Name3: | Greene |
| Subdivision Type4: | Townships |
| Subdivision Name4: | Morgan Washington |
| Length: | 13.2miles[1] |
| Discharge1 Avg: | 31.85cuft/s at mouth with South Fork Tenmile Creek[2] |
| Source1: | divide between Ruff Creek and Tenmile Creek |
| Source1 Location: | about 1 mile southeast of Dunn's Station, Pennsylvania |
| Source1 Coordinates: | 40.0086°N -80.2406°W[3] |
| Source1 Elevation: | 1230feet[4] |
| Mouth: | South Fork Tenmile Creek |
| Mouth Location: | about 3 miles northeast of Morrisville, Pennsylvania |
| Mouth Coordinates: | 39.9158°N -80.1053°W |
| Mouth Elevation: | 879feet[5] |
| Progression: | southeast |
| River System: | Monongahela River |
| Tributaries Left: | Craynes Run Poverty Run Grimes Run |
| Tributaries Right: | Walkers Run Jersey Run |
Ruff Creek is a large tributary to South Fork Tenmile Creek in southwestern Pennsylvania. The stream rises in north-central Greene County and flows southeast entering South Fork Tenmile Creek northeast of Morrisville, Pennsylvania. The watershed is roughly 27% agricultural, 64% forested and the rest is other uses.[2]