Rubredoxin—NAD(P)(+) reductase explained

rubredoxin—NAD(P)+ reductase
Ec Number:	1.18.1.4
Cas Number:	114514-31-7
Go Code:	0015045

In enzymology, a rubredoxin—NAD(P)+ reductase is an enzyme that catalyzes the chemical reaction

reduced rubredoxin + NAD(P)+

\rightleftharpoons oxidized rubredoxin + NAD(P)H + H⁺

The 3 substrates of this enzyme are reduced rubredoxin, NAD⁺, and NADP⁺, whereas its 4 products are oxidized rubredoxin, NADH, NADPH, and H⁺.^{[1] [2]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is rubredoxin:NAD(P)+ oxidoreductase. Other names in common use include rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase, rubredoxin-nicotinamide adenine, dinucleotide phosphate reductase, NAD(P)+-rubredoxin oxidoreductase, and NAD(P)H-rubredoxin oxidoreductase. This enzyme participates in fatty acid metabolism.

See also

• Rubredoxin—NAD(+) reductase

Notes and References

1. Petitdemange H, Blusson H, Gay R . Detection of NAD(P)H--rubredoxin oxidoreductases in Clostridia . Analytical Biochemistry . 116 . 2 . 564–70 . September 1981 . 6274224 . 10.1016/0003-2697(81)90403-6 .
2. Ma K, Adams MW . A hyperactive NAD(P)H:Rubredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus . Journal of Bacteriology . 181 . 17 . 5530–3 . September 1999 . 10464233 . 94068 .