RsmY RNA family explained

RsmY RNA family
Symbol:	RsmY
Rfam:	RF00195
Rna Type:	Gene sRNA
Tax Domain:	Bacteria

The rsmY RNA family is a set of related non-coding RNA genes, that like RsmZ, is regulated by the GacS/GacA signal transduction system in the plant-beneficial soil bacterium and biocontrol model organism Pseudomonas fluorescens CHA0. GacA/GacS target genes are translationally repressed by the small RNA binding protein RsmA. RsmY and RsmZ RNAs bind RsmA to relieve this repression and so enhance secondary metabolism and biocontrol traits.^[1]

Studies in Legionella pneumophila have shown that the ncRNAs RsmY and RsmZ together with the proteins LetA and CsrA are involved in a regulatory cascade. Also, it appears that these ncRNAs are regulated by RpoS sigma-factor.^[2]

See also

• CsrB/RsmB RNA family
• CsrC RNA family
• PrrB/RsmZ RNA family
• RsmX
• RsmW sRNA
• CsrA protein

Further reading

• Brencic A, McFarland KA, McManus HR, Castang S, Mogno I, Dove SL, Lory S . The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs . Molecular Microbiology . 73 . 3 . 434–445 . August 2009 . 19602144 . 2761719 . 10.1111/j.1365-2958.2009.06782.x .
• Sorger-Domenigg T, Sonnleitner E, Kaberdin VR, Bläsi U . Distinct and overlapping binding sites of Pseudomonas aeruginosa Hfq and RsmA proteins on the non-coding RNA RsmY . Biochemical and Biophysical Research Communications . 352 . 3 . 769–773 . January 2007 . 17141182 . 10.1016/j.bbrc.2006.11.084 .
• Valverde C, Lindell M, Wagner EG, Haas D . A repeated GGA motif is critical for the activity and stability of the riboregulator RsmY of Pseudomonas fluorescens . The Journal of Biological Chemistry . 279 . 24 . 25066–25074 . June 2004 . 15031281 . 10.1074/jbc.M401870200 . free .

External links

• • Pfam page for the CsrA protein family

Notes and References

1. Valverde C, Heeb S, Keel C, Haas D . RsmY, a small regulatory RNA, is required in concert with RsmZ for GacA-dependent expression of biocontrol traits in Pseudomonas fluorescens CHA0 . Molecular Microbiology . 50 . 4 . 1361–1379 . November 2003 . 14622422 . 10.1046/j.1365-2958.2003.03774.x .
2. Rasis M, Segal G . The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors . Molecular Microbiology . 72 . 4 . 995–1010 . May 2009 . 19400807 . 10.1111/j.1365-2958.2009.06705.x . 37262658 . free .