Rs7341475 Explained

Rsid:	7341475
Gene:	RELN
Chromosome:	7
Region:	Intron 4
Szgene Geneid:	18
Szgene Polyid:	5691

In genetics, rs7341475 is a single nucleotide polymorphism (SNP) in the RELN gene that codes the reelin protein. The gene RELN is mapped to human chromosome 7 (7q22.1). The SNP rs7341475 is located in the fourth intron of RELN. The gene RELN has many more SNPs among its 65 exons and 64 introns, - even in intron 4 there are tens of SNPs.^[1]

The SNP has been investigated for a possible link to schizophrenia.A 2008 genome-wide association study pointed to that a variant of the SNP could elevate the risk for schizophrenia among women.^[2] A 2015 publication reported a meta-analysis across five studies concluding a slight effect of the SNP.

Notes and References

1. Web site: SNP linked to Gene RELN . NCBI . 2008-09-09.
2. . Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women . . 4 . 2 . e28 . February 2008 . 10.1371/journal.pgen.0040028 . 18282107 . 2242812. free . News:
   • News: Genetic Variant Found for Women's Schizophrenia . Eric Metcalf . MentalHelp.net . 2008-02-19 . 2008-09-09 . dead . https://web.archive.org/web/20110716061326/http://www.mentalhelp.net/poc/view_doc.php?type=news&id=108022&cn=7 . 2011-07-16.
   • News: Gene variant linked to female schizophrenia . PsychiatryMatters.md . 2008-02-25 . 2008-09-09 . dead . https://archive.today/20130219030028/http://www.psychiatrymatters.md/headlines/fullpage.asp?C=45637397004821296296&xml=/headlines/2008/02_february/week_08/gene_variant_linked_to_female_schizophrenia.xml . 2013-02-19.