Rs1799913 Explained

Rsid:	1799913
Name 1:	A779C
Gene:	TPH1
Chromosome:	11
Region:	Intron 7
Szgene Geneid:	111
Szgene Polyid:	586

In genetics, rs1799913, also called A779C, is a gene variation - a single nucleotide polymorphism (SNP) - in the TPH1 gene.It is located in intron 7.^[1]

The SNP association with schizophrenia has been examined in several studies, though as of 2007 with no definitive conclusion.^[2]

One study has found that the SNP may be associated with heroin addiction.^[3] Other study relate it to figural and numeric creativity.^[4]

A218C (rs1800532) is another SNP in the same intron in the same gene.^[1]

Notes and References

1. . Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7 . . 45 . 1 . 145–148 . April 1997 . 9105682 . 10.1016/S0169-328X(96)00304-X.
2. . Comments on the paper by D. Li and L. He: Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia . . 122 . 3–4 . November 2007 . 10.1007/s00439-007-0383-6 . 409 - 411 . 17653577. 13181665 .
3. . TPH2 and TPH1: association of variants and interactions with heroin addiction . . 38 . 2 . 133–50 . March 2008 . 10.1007/s10519-007-9187-7 . 18181017. 2774846 .
4. . Identification of first candidate genes for creativity: a pilot study. . . 2006 . 1069 . 1 . 190–197 . 10.1016/j.brainres.2005.11.046 . 16403463. 25365017 .