Roxadustat Explained

Width:250
Tradename:Evrenzo
Routes Of Administration:By mouth
Atc Prefix:B03
Atc Suffix:XA05
Legal Eu:Rx-only
Legal Status:Rx-only
Cas Number:808118-40-3
Pubchem:11256664
Drugbank:DB04847
Chemspiderid:9431690
Unii:X3O30D9YMX
Kegg:D10593
Synonyms:FG-4592, ASP1517, AZD9941
Iupac Name:2-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
C:19
H:16
N:2
O:5
Smiles:CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O
Stdinchi:1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
Stdinchikey:YOZBGTLTNGAVFU-UHFFFAOYSA-N

Roxadustat, sold under the brand name Evrenzo, is an anti-anemia medication. Roxadustat is a HIF prolyl-hydroxylase inhibitor that increases endogenous production of erythropoietin and stimulates production of hemoglobin and red blood cells. It was investigated in clinical trials for the treatment of anemia caused by chronic kidney disease (CKD).[1] [2] It is taken by mouth. The drug was developed by FibroGen, in partnership with AstraZeneca.

The most common side effects include hypertension (high blood pressure), vascular access thrombosis (formation of blood clots in the blood vessels associated with dialysis), diarrhea, peripheral edema (swelling especially of the ankles and feet), hyperkalemia (high blood potassium levels) and nausea (feeling sick).

Roxadustat received its first global approval in China on 17 December 2018,[3] for the treatment of anemia caused by CKD in patients who are dialysis-dependent.[4] It was approved in Japan in 2019, for the treatment of anemia caused by CKD in patients on dialysis, and in 2020 for patients not on dialysis.[5] Roxadustat was approved for medical use in the European Union in August 2021.[6]

Medical uses

Roxadustat is indicated for treatment of adults with symptomatic anemia associated with chronic kidney disease (CKD).[7]

Adverse effects

Roxadustat is reported to increase VEGF, a signal protein that can activate tumor growth[8] and also is considered to cause pulmonary hypertension.[9] In phase 3 trial conducted at 29 sites in China, roxadustat treatment was found to cause hyperkalemia, i.e., increase in serum potassium, and metabolic acidosis in patients.[10]

Society and culture

Legal status

In July 2021, the Cardiovascular and Renal Drugs Advisory Committee of the US Food and Drug Administration (FDA) voted against the use of roxadustat in people with anemia in chronic kidney disease, both for those that are non-dialysis-dependent and those that are on dialysis.[11] Significant safety concerns were raised that the panelists believed could not be addressed without further study.[12] Notably, prior to the vote of the FDA committee, FibroGen and AstraZeneca announced that the company had changed parameters used to analyze cardiovascular safety data, which made the drug appear safer than it is.[13]

Usage as a doping product

Due to the potential applications of roxadustat in athletic doping, such as raising haemoglobin levels and stimulating the production of red blood cells, it has been incorporated into screens for performance-enhancing drugs, as it has already been detected being used illicitly by athletes.[14] [15] [16] In October 2022, it was announced that Romanian former world No. 1 tennis player Simona Halep had tested positive for roxadustat at the 2022 US Open.[17] In September 2023, she was banned from the game for four years by the International Tennis Integrity Agency (ITIA) for two anti-doping violations: taking roxadustat, and anomalies in her athlete biological passport,[18] although the Court of Arbitration for Sport reduced the ban to nine months in March 2024, on the grounds that roxadustat was in Keto MCT, a contaminated supplement, and the doping was unintentional.[19]

Further reading

Notes and References

  1. Provenzano R, Besarab A, Sun CH, Diamond SA, Durham JH, Cangiano JL, Aiello JR, Novak JE, Lee T, Leong R, Roberts BK, Saikali KG, Hemmerich S, Szczech LA, Yu KP, Neff TB . Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD . Clinical Journal of the American Society of Nephrology . 11 . 6 . 982–991 . June 2016 . 27094610 . 4891748 . 10.2215/CJN.06890615 .
  2. Becker K, Saad M . A New Approach to the Management of Anemia in CKD Patients: A Review on Roxadustat . Advances in Therapy . 34 . 4 . 848–853 . April 2017 . 28290095 . 10.1007/s12325-017-0508-9 . free .
  3. Dhillon S . Roxadustat: First Global Approval . Drugs . 79 . 5 . 563–572 . April 2019 . 30805897 . 10.1007/s40265-019-01077-1 . 71147333 . free .
  4. Dhillon S . Roxadustat: First Global Approval . Drugs . 79 . 5 . 563–572 . April 2019 . 30805897 . 10.1007/s40265-019-01077-1 . 71147333 . free .
  5. News: Astellas Receives Approval of Evrenzo (roxadustat) in Japan for the Treatment of Anemia of Chronic Kidney Disease in Adult Patients Not on Dialysis. Astellas. 27 November 2020.
  6. Web site: Evrenzo Product information . Union Register of medicinal products . 3 March 2023.
  7. Web site: Evrenzo EPAR . European Medicines Agency (EMA) . 23 June 2021 . 24 August 2021. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  8. Zhou M, Hou J, Li Y, Mou S, Wang Z, Horch RE, Sun J, Yuan Q . The pro-angiogenic role of hypoxia inducible factor stabilizer FG-4592 and its application in an in vivo tissue engineering chamber model . Scientific Reports . 9 . 1 . 6035 . April 2019 . 30988335 . 6465281 . 10.1038/s41598-019-41924-5 . 2019NatSR...9.6035Z .
  9. Cygulska K, Wejner-Mik P, Plewka M, Figiel Ł, Chrzanowski Ł, Kasprzak JD . Roxadustat: another drug that causes pulmonary hypertension? Report of first human case . Polish Archives of Internal Medicine . 129 . 5 . 344–345 . May 2019 . 30758318 . 10.20452/pamw.4445 . free .
  10. Chen N, Hao C, Peng X, Lin H, Yin A, Hao L, Tao Y, Liang X, Liu Z, Xing C, Chen J, Luo L, Zuo L, Liao Y, Liu BC, Leong R, Wang C, Liu C, Neff T, Szczech L, Yu KP . Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis . The New England Journal of Medicine . 381 . 11 . 1001–1010 . September 2019 . 31340089 . 10.1056/NEJMoa1813599 . free .
  11. FibroGen Announces Outcome of FDA Advisory Committee Review of Roxadustat for Treatment of Anemia of Chronic Kidney Disease . 15 July 2021. FibroGen.
  12. Web site: Sagonowsky E . 15 July 2021 . AstraZeneca, FibroGen hit another roxadustat setback as FDA panel calls for more safety data. 16 July 2021. FiercePharma.
  13. Web site: Liu A . 7 April 2021 . FibroGen admits to messing with roxadustat safety data, upending hopes for the AZ-partnered anemia drug . 30 October 2022 . Fierce Pharma .
  14. Beuck S, Schänzer W, Thevis M . Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis . Drug Testing and Analysis . 4 . 11 . 830–845 . November 2012 . 22362605 . 10.1002/dta.390 . free .
  15. Buisson C, Marchand A, Bailloux I, Lahaussois A, Martin L, Molina A . Detection by LC-MS/MS of HIF stabilizer FG-4592 used as a new doping agent: Investigation on a positive case . Journal of Pharmaceutical and Biomedical Analysis . 121 . 181–187 . March 2016 . 26808067 . 10.1016/j.jpba.2016.01.029 .
  16. Eichner D, Van Wagoner RM, Brenner M, Chou J, Leigh S, Wright LR, Flippin LA, Martinelli M, Krug O, Schänzer W, Thevis M . lmplementation of the prolyl hydroxylase inhibitor Roxadustat (FG-4592) and its main metabolites into routine doping controls . Drug Testing and Analysis . 9 . 11–12 . 1768–1778 . November 2017 . 28378453 . 10.1002/dta.2202 . free .
  17. News: MacInnes P . Simona Halep vows to 'fight for the truth' after positive doping test . 21 October 2022 . The Guardian . 21 October 2022.
  18. News: Ingle S . Simona Halep given four-year ban from tennis for anti-doping violations . 12 September 2023 . The Guardian . 12 September 2023.
  19. News: Carayol . Tumaini . Simona Halep's 'triumph of truth' after doping ban significantly reduced . 6 March 2024 . The Guardian . 5 March 2024.

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