| Country: | PRY |
| Type: | National |
| Route: | 05 |
| Alternate Name: | Gral. Bernardino Caballero |
| Map: | Mapa de la Ruta 5 de Paraguay.svg |
| Map Notes: | PY05 highlighted in red |
| Length Km: | 577 |
| Direction A: | West |
| Terminus A: | Fortín Pilcomayo |
| Junction: | Route 9 in Pozo Colorado, PH Route 3 in Yby Yaú, CO |
| Direction B: | East |
| Terminus B: | Pedro Juan Caballero |
National Route 5 (in Spanish, Ruta Nacional Número 5 "Gral. Bernardino Caballero", or simply Ruta Quinta) is a highway in northern Paraguay, it runs from Fortín Pilcomayo to Pedro Juan Caballero. It crosses 3 departments, Presidente Hayes, Concepcion, and Amambay.
The following table shows the distances traversed by National Route 5 in each different department, and important cities that it passes by (or near).
| Km | City | Department | Junctions |
|---|---|---|---|
| 0 | |||
| 48 | Fortín Gral. Díaz | PY12 | |
| 101 | Fortín Mayor Ávalos | PY16 | |
| 235 | PY09 | ||
| 380 | PY22 | ||
| 425 | |||
| 492 | PY08 (S) | ||
| 531 | PY08 (N) | ||
| 577 | PY17 | ||