| State: | MO |
| Type: | Route |
| Route: | 42 |
| Map Custom: | yes |
| Length Mi: | 60.394 |
| Direction A: | West |
| Terminus A: | in Osage Beach |
| Junction: |
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| Direction B: | East |
| Terminus B: | in Belle |
| Previous Type: | MO |
| Previous Route: | 41 |
| Next Type: | MO |
| Next Route: | 43 |
Route 42 is a highway in central Missouri. Its eastern terminus is at Route 28 south of Belle; its western terminus is at US 54 in Osage Beach.
Route 42 begins at the interchange of US 54 in Osage Beach, at a concurrency with Osage Beach Parkway. It intersects the terminus of Route 134 which allows access to the Lake of the Ozarks State Park. It passes through Brumley and Iberia where it intersects with Route 17 in Iberia. Route 42 has a brief concurrency with Route 133. Route 42 passes through Vienna where it intersects with US 63. Route 42 ends at Route 28 south of Belle.