| State: | MO |
| Type: | MO |
| Route: | 33 |
| Map Custom: | yes |
| Established: | 1922 |
| Length Mi: | 49.464 |
| Direction A: | South |
| Terminus A: | in Liberty |
| Junction: | near Osborn |
| Direction B: | North |
| Terminus B: | in Maysville |
| Previous Type: | MO |
| Previous Route: | 32 |
| Next Type: | MO |
| Next Route: | 34 |
Route 33 is a highway in western Missouri. Its northern terminus is at Route 6 in Maysville; its southern terminus is at U.S. Route 69 in Liberty.
Route 33 is one of the original 1922 state highways. Its northern terminus was at Route 8 (now U.S. Route 136) in southern DeKalb County. At Plattsburg, it turned west (modern Route 116) and then south on current U.S. Route 169.
A branch route, Route 33A, left the former alignment and connected it with Lathrop. This branch is now part of the highway itself.