| State: | MO |
| Type: | MO |
| Route: | 28 |
| Map Custom: | yes |
| Maint: | MoDOT |
| Established: | 1922 |
| Length Mi: | 70 |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | near St. Robert |
| Junction: | from Vienna to Vichy |
| Terminus B: | in Rosebud |
| Previous Type: | AOTS |
| Previous Route: | 27 |
| Next Type: | I |
| Next Route: | 29 |
Route 28 is a highway in central Missouri. Its eastern terminus is at U.S. Route 50 in eastern Gasconade County; its western terminus is at Interstate 44 east of St. Robert. Route 28 was one of the original state highways and it has changed very little. Its termini are currently the same as they were in 1922.