| State: | MO |
| Type: | Route |
| Route: | 273 |
| Map Custom: | yes |
| Map Notes: | MO 273 highlighted in red |
| Length Mi: | 23.728 |
| Direction A: | South |
| Terminus A: | near Tracy |
| Direction B: | North |
| Terminus B: | at the Kansas state line |
| Previous Type: | I |
| Previous Route: | 270 |
| Next Type: | US |
| Next Route: | 275 |
Route 273 is a highway in northwestern Missouri. Its northern terminus is at the Kansas state line halfway across the Missouri River near Atchison, Kansas. At this point it is concurrent with U.S. Route 59. The southern terminus is at I-29/US 71 near Tracy. All but the southeasternmost six miles (10 km) overlap Route 45. The road runs through Platte and Buchanan Counties.