| Country: | PRY |
| Type: | National |
| Route: | 22 |
| Map: | Mapa de la Ruta 22 de Paraguay.svg |
| Map Notes: | PY22 highlighted in red |
| Length Km: | 424 |
| Established: | 2019 |
| Direction A: | South |
| Terminus A: | San Estanislao |
| Direction B: | North |
| Terminus B: | San Lázaro |
National Route 22[1] (officially, PY22) is a highway in Paraguay, which connects two northern departments of Paraguay, San Pedro and Concepción.
With the Resolution N° 1090/19,[2] it obtained its current number and elevated to National Route in 2019 by the MOPC (Ministry of Public Works and Communications).
The following table shows the distances traversed by PY22 in each different department, showing cities and towns that it passes by (or near).
| Km | City | Department | Junctions | |
|---|---|---|---|---|
| 0 | PY03 | |||
| 37 | ||||
| 50 | ||||
| 71 | ||||
| 123 | ||||
| 142 | PY11 | |||
| 222 | ||||
| 241 | PY05 | |||
| 263 | ||||
| 424 |