| Country: | ISR |
| Type: | Hwy |
| Route: | 171 |
| Map: | ILroute-171.png |
| Length Km: | 33 |
| Direction A: | West |
| Terminus A: | Har Harif Junction |
| Direction B: | East |
| Terminus B: | HaRuhot Junction |
| Cities: | Mitzpe Ramon |
| Previous Route: | 109 |
| Previous Type: | Route |
| Next Route: | 200 |
| Next Type: | Route |
Route 171 is a regional east-west road in southern Israel. It is the only east-west road in the Negev Mountains. It is long. It goes from Mount Harif (Hebrew: הר חריף) junction on Highway 10 adjacent to Israel's border with Egypt to HaRuhot junction with Highway 40 about 5 km north of Mitzpe Ramon. The road passes mostly along the northern edge of Makhtesh Ramon and along the flowing path of . In its eastern portion, it crosses HaRuhot Plain and passes by the Mitzpe Ramon Airport.
About northeast of Har Harif junction, 950 meters above mean sea level, are the Lotz Cisterns. This is a group of 17 water cisterns spread over an area of 2 square km, that were dug during the reign of Solomon in the 10th century BCE. 15 of the water pits are still filled with water in the winter rainy season.