| State: | MO |
| Route: | 149 |
| Type: | Route |
| Length Mi: | 84 |
| Map Custom: | yes |
| Map Notes: | MO 149 highlighted in red |
| Direction A: | South |
| Terminus A: | south of New Cambria |
| Junction: | near Livonia |
| Direction B: | North |
| Terminus B: | at the Iowa state line |
| Previous Type: | MO |
| Previous Route: | 148 |
| Next Type: | MO |
| Next Route: | 150 |
Route 149 is a highway in northern Missouri. Its northern terminus is at the Iowa state line where it continues as Appanoose County Route T30; its southern terminus is at U.S. Route 36 south of New Cambria.