| State: | MO |
| Route: | 142 |
| Type: | Route |
| Map Custom: | yes |
| Map Notes: | MO 142 highlighted in red |
| Length Mi: | 122.328 |
| Direction B: | West |
| Terminus B: | in Poplar Bluff |
| Direction A: | East |
| Terminus A: | in Bakersfield |
| Previous Type: | MO |
| Previous Route: | 141 |
| Next Type: | MO |
| Next Route: | 143 |
Route 142 is a highway in southern Missouri. Its eastern terminus is at Route 53 in southern Poplar Bluff; its western terminus is at Route 101 in Bakersfield. Route 142 is the southernmost east–west highway in the south-central part of the state. Despite its length, there are relatively few towns on the route.