| Province: | QC |
| Type: | QC |
| Route: | 112 |
| Maint: | Transports Québec |
| Map: | Route 112-QC.png |
| Length Km: | 319.0 |
| Length Round: | 1 |
| Length Ref: | [1] |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | in Montreal |
| Terminus B: | in Frampton |
| Junction: | in Saint-Lambert in Longueuil in Richelieu in Granby in Magog in Sherbrooke in Sherbrooke in Weedon and Beaulac-Garthby in Thetford Mines in Vallée-Jonction in Saints-Anges |
| Previous Type: | QC |
| Previous Route: | 111 |
| Next Type: | QC |
| Next Route: | 113 |
Route 112 is a busy east–west highway on the south shore of the Saint Lawrence River in Quebec, Canada. Its eastern terminus is in Frampton at the junction of Route 275, and the western terminus is in Downtown Montreal (at the corner of Peel Street and Sherbrooke Street), after crossing the Victoria Bridge. The stretch between Vallée-Jonction and Sherbrooke is a very busy highway as it is the main link between the southern regions of Quebec, in particular the Beauce region and the Eastern Townships. Between Sherbrooke and Marieville there is less traffic, since Autoroute 10 is in close proximity to the highway. (Before Autoroute 10 was put in service in the early 1960s, Route 1 (now Route 112) was the main link between Montreal and the Eastern Townships; see paragraph below.) From Marieville to Montreal it is a very busy highway, in most parts a four-lane separated highway, upgraded to freeway standards in certain places.
Route 112 is Granby's main street (rue Principale), Magog's main street (rue Principale), and Sherbrooke's main street (rue King). It has been the road connecting most of the Eastern Townships to Montreal for decades as Route 1.