| Formation: | 2002 |
| Founder: | Jonathan Rothberg |
| Type: | 501(c)(3) |
| Headquarters: | Guilford, Connecticut |
| Website: | http://www.childhooddiseases.org/ |
The Rothberg Institute For Childhood Diseases is a non-profit organization dedicated to finding a cure for rare childhood diseases such as Tuberous Sclerosis Complex (TSC). The organization was founded by Jonathan Rothberg and his wife in 2002 after their son was born with TSC.[1] [2] [3] [4]
Located in Guilford, Connecticut, the organization was responsible for the CommunityTSC distributed computing project.
Dr. Rothberg graduated from Yale University in 1991.
CommunityTSC Drug Design Optimization Lab (D2OL) was a distributed computing project developed by the Institute to test drug candidates interaction with a target molecule that is essential to the spread of the disease under scrutiny. By evaluating the energy level released by binding a small molecule drug candidate to the surface of a larger Target molecule (D2OL) determines the fitness of the particular candidate to a region of the Target structure known as the Active Site. This process is referred to as docking the drug candidate to the target. D2OL ended on April 15, 2009.