Ross' syndrome explained

Ross' syndrome consists of Adie's syndrome (myotonic pupils and absent deep tendon reflexes) plus segmental anhidrosis (typically associated with compensatory hyperhidrosis).^[1]

It was characterized in 1958^{[2] [3]} by A.T. Ross.^[4]

By 1992, eighteen cases had been documented.^[5]

Signs and Symptoms

Initial manifestations often include an abnormal segmental sweating response (described as hyperhidrosis or anhidrosis in some patients) and a tonic pupil. Other commonly reported symptoms included fatigue, chronic cough, and increased urinary frequency.^[6]

Prognosis

Ross syndrome is a non life-threatening benign condition but delay in diagnosis can result in slow progression of autonomic symptoms. ^[7]

Epidemiology

Ross Syndrome is a progressive autonomic dysfunction that can occur in any age, ethnicity, or gender. The average age of diagnosis for Ross syndrome is 36 years and affects more females than males.

See also

• Hypohidrosis
• List of cutaneous conditions

Notes and References

1. Book: Bolognia JL, Jorizzo JL, Rapini RP . 2nd . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 539 . 978-1-4160-2999-1 .
2. Book: Otto Braun-Falco. Dermatology. 20 November 2010. 2000. Springer. 978-3-540-59452-9. 1093–.
3. Yaşar S, Aslan C, Serdar ZA, Demirci GT, Tutkavul K, Babalik D . Ross syndrome: Unilateral hyperhidrosis, Adie's tonic pupils and diffuse areflexia . J Dtsch Dermatol Ges . 8. 12. 1004–1006. April 2010 . 20408939 . 10.1111/j.1610-0387.2010.07400.x . 24213039 .
4. Ross AT . Progressive selective sudomotor denervation; a case with coexisting Adie's syndrome . Neurology . 8 . 11 . 809–17 . November 1958 . 13590391 . 10.1212/wnl.8.11.809. 2610900 .
5. Weller M, Wilhelm H, Sommer N, Dichgans J, Wiethölter H . Tonic pupil, areflexia, and segmental anhidrosis: two additional cases of Ross syndrome and review of the literature . J. Neurol. . 239 . 4 . 231–4 . April 1992 . 1597691 . 10.1007/BF00839146. 8832477 .
6. Lamotte. Guillaume. Sandroni. Paola. Cutsforth-Gregory. Jeremy K.. Berini. Sarah E.. Benarroch. Eduardo E.. Shouman. Kamal. Mauermann. Michelle L.. Anderson. Jennifer. Low. Phillip A.. Singer. Wolfgang. Coon. Elizabeth A.. 2021-10-01. Clinical presentation and autonomic profile in Ross syndrome. Journal of Neurology. en. 268. 10. 3852–3860. 10.1007/s00415-021-10531-8. 33813643 . 9639164 . 1432-1459.
7. Web site: Ross syndrome DermNet NZ. 2021-12-07. dermnetnz.org. en.