| Rosa Zafferani | |
| Office: | Captain Regent of San Marino |
| Term Start: | 1 April 2008 |
| Term End: | 1 October 2008 Served with Federico Pedini Amati |
| Predecessor: | Mirko Tomassoni Alberto Selva |
| Successor: | Ernesto Benedettini Assunta Meloni |
| Term Start1: | 1 April 1999 |
| Term End1: | 1 October 1999 Served with Antonello Bacciocchi |
| Predecessor1: | Paolo Bollini Pietro Berti |
| Successor1: | Giuseppe Arzilli Marino Bollini |
| Birth Date: | 16 August 1960 |
| Birth Place: | Jersey City, New Jersey, U.S. |
| Alma Mater: | University of Bologna |
Rosa Zafferani (born 16 August 1960) is a Sammarinese politician. She was a member of the Sammarinese Christian Democratic Party until she left with the rest of the left-wing faction of the party to form the Centre Democrats.
Zafferani served as Secretary of State for health, education and the interior. She served as Captain Regent for the April through October 1999 term before reassuming the role for a second time,[1] together with Federico Pedini Amati, from April through October 2008.[2]