| Jurisdiction: | Diocese |
| Zacatecoluca | |
| Latin: | Dioecesis Zacatecolucana |
| Country: | El Salvador |
| Metropolitan: | José Luis Escobar Alas |
| Province: | Province of San Salvador |
| Area Km2: | 1,536 |
| Population: | 336,000 |
| Population As Of: | 2010 |
| Catholics: | 283,000 |
| Catholics Percent: | 84.2 |
| Parishes: | 32 |
| Denomination: | Catholic Church |
| Sui Iuris Church: | Latin Church |
| Rite: | Roman Rite |
| Established: | 5 May 1987 (years ago) |
| Bishop Title: | Bishop |
| Bishop: | Elías Samuel Bolaños Avelar, S.D.B. |
| Map: | El Salvador - Diocesi di Zacatecoluca.jpg |
The Diocese of Zacatecoluca (Latin: Dioecesis Zacatecolucana) is a Latin Church ecclesiastical territory or diocese of the Catholic Church in El Salvador. It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of San Salvador. The Diocese of Zacatecoluca was erected on 5 May 1987.