| Jurisdiction: | Diocese |
| Uyo | |
| Latin: | Dioecesis Uyoensis |
| Country: | Nigeria |
| Territory: | Portions of Akwa Ibom State |
| Metropolitan: | Archbishop of Calabar |
| Coordinates: | 5.0232°N 7.9239°W |
| Area Km2: | 5,969 |
| Area Sqmi: | 2,305 |
| Population: | 1,779,856 |
| Population As Of: | 2004 |
| Catholics: | 598,028 |
| Catholics Percent: | 33.6 |
| Parishes: | 72 |
| Congregations: | 5 female; 3 male |
| Schools: | 5 secondary schools |
| Denomination: | Catholic Church |
| Sui Iuris Church: | Latin Church |
| Rite: | Roman Rite |
| Established: | July 4, 1989 |
| Priests: | 75 |
| Bishop: | Bishop John Ebebe Ayah |
| Metro Archbishop: | Archbishop Joseph Effiong Ekuwem |
| Suffragan: | for one --> |
| Archdeacon: | for one--> |
| Map: | Nigeria Akwa Ibom State map.png |
| Website: | www.CatholicDioceseofUyo.org |
The Diocese of Uyo (la|Uyoën(sis)) is a Latin Church ecclesiastical territory or diocese of the Catholic Church in Nigeria. Its episcopal see is Uyo. The Diocese of Uyo is suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of Calabar.
The diocesan cathedral is Christ the King Cathedral in Uyo.