| Jurisdiction: | Diocese |
| Tlaxcala | |
| Latin: | Dioecesis Tlaxcalensis |
| Local: | Diócesis de Tlaxcala |
| Country: | Mexico |
| Province: | Puebla de los Ángeles |
| Area Sqmi: | 1,568 |
| Population: | 1,077,000 |
| Population As Of: | 2010 |
| Catholics: | 1,055,000 |
| Catholics Percent: | 98 |
| Parishes: | 76 |
| Denomination: | Catholic Church |
| Sui Iuris Church: | Latin Church |
| Rite: | Roman Rite |
| Established: | 23 May 1959 (years ago) |
| Cathedral: | Cathedral of Our Lady of the Assumption |
| Bishop: | Francisco Moreno Barrón |
| Metro Archbishop: | Victor Sánchez Espinosa |
| Map: | Roman Catholic Diocese of Tlaxcala in Mexico.jpg |
The Diocese of Tlaxcala (Latin: Dioecesis Tlaxcalensis) is a Latin Church ecclesiastical territory or diocese of the Catholic Church in Mexico. It is a suffragan in the ecclesiastical province of the metropolitan Archdiocese of Puebla de los Ángeles,[1] which was itself officially named the "Diocese of Tlaxcala" until 1903 (founded in 1519 and so named in 1525, the oldest diocese in Mexico).[2] The present Diocese of Tlaxcala was erected on 23 May 1959 from territory of that archdiocese and the adjacent Archdiocese of Mexico.[1] Its cathedra is found within the Cathedral of Our Lady of the Assumption in the episcopal see of Tlaxcala.