| Jurisdiction: | Diocese |
| Santisimo Salvador de Bayamo y Manzanillo | |
| Latin: | Dioecesis Sanctissimi Salvatoris Bayamensis-Manzanillensis |
| Country: | Cuba |
| Metropolitan: | Bayamo |
| Province: | Province of Santiago de Cuba |
| Area Km2: | 8,362 |
| Population: | 832,644 |
| Population As Of: | 2004 |
| Catholics: | 222.000 |
| Catholics Percent: | 26.7 |
| Parishes: | 9 |
| Denomination: | Roman Catholic |
| Rite: | Latin Rite |
| Established: | 9 December 1995 (years ago) |
| Cathedral: | Cathedral of the Most Holy Saviour |
| Bishop Title: | Bishop |
The Roman Catholic Diocese of Santisimo Salvador de Bayamo y Manzanillo (erected 9 December 1995) is a suffragan diocese of the Archdiocese of Santiago de Cuba.