| Jurisdiction: | Diocese |
| Santiago de María | |
| Latin: | Dioecesis Sancti Iacobi de Maria |
| Country: | El Salvador |
| Metropolitan: | José Luis Escobar Alas |
| Province: | Province of San Salvador |
| Area Km2: | 2,866 |
| Population: | 563,000 |
| Population As Of: | 2014 |
| Catholics: | 449,700 |
| Catholics Percent: | 79.9 |
| Parishes: | 40 |
| Denomination: | Catholic Church |
| Sui Iuris Church: | Latin Church |
| Rite: | Roman Rite |
| Established: | 2 December 1954 (years ago) |
| Priests: | 85 |
| Bishop Title: | Bishop |
| Map: | El Salvador - Diocesi di Santiago de Maria.jpg |
The Diocese of Santiago de María is a Latin Church ecclesiastical territory or diocese of the Catholic Church in El Salvador. It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of San Salvador. The Diocese of Santiago de María was erected on 2 December 1954.