| Jurisdiction: | Diocese |
| San Lorenzo | |
| Latin: | Dioecesis Sancti Laurentii |
| Country: | Paraguay |
| Rite: | Latin Rite |
| Cathedral: | Catedral San Lorenzo |
| Area Km2: | 1,924 |
| Population: | 792,374 |
| Population As Of: | 2004 |
| Catholics: | 713,136 |
| Catholics Percent: | 90.0 |
| Bishop: | Joaquín Hermes Robledo Romero |
| Map: | Diócesis de San Lorenzo.svg |
The Roman Catholic Diocese of San Lorenzo (Latin: Dioecesis Sancti Laurentii) is a diocese located in the city of San Lorenzo in the ecclesiastical province of Asunción in Paraguay.