| Jurisdiction: | Diocese |
| San Francisco de Macorís | |
| Latin: | Dioecesis Sancti Francisci de Macoris |
| Country: | Dominican Republic |
| Metropolitan: | San Francisco de Macorís |
| Province: | Province of Santiago de los Caballeros |
| Area Km2: | 3,682 |
| Population: | 743,000 |
| Population As Of: | 2010 |
| Catholics: | 591,000 |
| Catholics Percent: | 79.5 |
| Parishes: | 48 |
| Denomination: | Roman Catholic |
| Rite: | Latin Rite |
| Established: | 16 January 1978 (years ago) |
| Cathedral: | Cathedral of St. Ann |
| Bishop: | Ramón Alfredo de la Cruz Baldera |
| Map: | Diócesis de San Francisco de Macorís.svg |
The Roman Catholic Diocese of San Francisco de Macorís (Latin: Dioecesis Sancti Francisci de Macoris) (erected 16 January 1978) is a suffragan diocese of the Archdiocese of Santiago de los Caballeros.