| Jurisdiction: | Diocese |
| San Andrés Tuxtla | |
| Latin: | Dioecesis Sancti Andreae de Tuxtla |
| Local: | Diócesis de San Andrés Tuxtla |
| Country: | Mexico |
| Metropolitan: | San Andrés Tuxtla |
| Province: | Province of Jalapa |
| Area Sqmi: | 5,212 |
| Population: | 1,085,000 |
| Population As Of: | 2010 |
| Catholics: | 1,010,000 |
| Catholics Percent: | 93.1 |
| Parishes: | 56 |
| Denomination: | Roman Catholic |
| Rite: | Roman Rite |
| Established: | 23 May 1959 (years ago) |
| Cathedral: | Cathedral of St. Joseph and St. Andrew |
| Bishop: | José Luis Canto Sosa |
| Metro Archbishop: | Vacant |
| Map: | Roman Catholic Diocese of San Andres Tuxtla in Mexico.jpg |
The Roman Catholic Diocese of San Andrés Tuxtla (Latin: Dioecesis Sancti Andreae de Tuxtla) (erected 23 May 1959) is a suffragan diocese of the Archdiocese of Jalapa. In 1962, it lost territory to form the Archdiocese of Jalapa and the Diocese of Veracruz. It also lost territory in 1984 with the formation of the Diocese of Coatzacoalcos.