| Jurisdiction: | Diocese |
| Penonomé | |
| Latin: | Dioecesis Poenonomensis |
| Country: | Panama |
| Metropolitan: | Jose Domingo Ulloa Mendieta, O.S.A. |
| Province: | Province of Panamá |
| Area Km2: | 4,927 |
| Population: | 204,551 |
| Population As Of: | 2003 |
| Catholics: | 178,600 |
| Catholics Percent: | 87.3 |
| Parishes: | 8 |
| Denomination: | Roman Catholic |
| Rite: | Roman Rite |
| Established: | 18 December 1993 (years ago) |
| Cathedral: | Cathedral of St. John Baptist |
| Bishop Title: | Bishop |
| Bishop: | Uriah Ashley |
| Map: | Panama - Diocesi di Penonomé.png |
The Roman Catholic Diocese of Penonomé (erected 18 December 1993) is a suffragan diocese of the Archdiocese of Panamá.