| Jurisdiction: | Diocese |
| Machiques | |
| Latin: | Dioecesis Machiquesensis |
| Country: | Venezuela |
| Rite: | Latin Rite |
| Established: | 26 May 1943 (years ago) |
| Cathedral: | Our Lady of Mount Carmel Cathedral |
| Area Km2: | 25,350 |
| Population: | 325,000 |
| Population As Of: | 2010 |
| Catholics: | 282,000 |
| Catholics Percent: | 86.8 |
| Emeritus Bishops: | Ramiro Díaz Sánchez, OMI |
The Roman Catholic Diocese of Machiques (Latin: Dioecesis Machiquesensis) is a diocese located in the Roman Catholic Archdiocese of Maracaibo in Venezuela.
On 26 May 1943 Pope Pius XII erected the diocese as an Apostolic Vicariate. The Vicariate was elevated to a full diocese by Pope Benedict XVI on 9 April 2011.