| Jurisdiction: | Diocese |
| Koforidua | |
| Latin: | Dioecesis Koforiduana |
| Country: |  Ghana |
| Province: | Archdiocese of Accra |
| Area Km2: | 18,600 |
| Population: | 2,100,000 |
| Population As Of: | 2004 |
| Catholics: | 201,335 |
| Catholics Percent: | 9.6 |
| Schools: | 330 |
| Denomination: | Roman Catholic |
| Rite: | Roman Rite |
| Established: | November 21, 1992 |
| Cathedral: | St. George's Cathedral, Koforidua |
| Priests: | 51 |
| Bishop: | Joseph Kwaku Afrifah-Agyekum |
| Metro Archbishop: | John Bonaventure Kwofie Archbishop of Accra |
The Roman Catholic Diocese of Koforidua (Latin: Dioecesis Koforiduana) is a diocese located in the city of Koforidua in the ecclesiastical province of Accra in Ghana.
The Cathedral is St. George’s Cathedral in Koforidua.