| Jurisdiction: | Diocese |
| Khandwa | |
| Latin: | Dioecesis Khandvaënsis |
| Country: |  India |
| Province: | Bhopal |
| Rite: | Latin Rite |
| Cathedral: | St Mary’s Cathedral in Khandwa |
| Area Km2: | 24,000 |
| Map: | Map of Roman Catholic Diocese of Khandwa.png |
| Population: | 4,521,350 |
| Population As Of: | 2006 |
| Catholics: | 30,601 |
| Catholics Percent: | 0.7 |
| Bishop: | Bishop Mar Augustine Madathikunnel |
| Metro Archbishop: | Alangaram Arockia Sebastian Durairaj |
| Website: | Website of the Diocese |
The Roman Catholic Diocese of Khandwa (Latin: Khandvaën(sis)) is a diocese located in the city of Khandwa in the ecclesiastical province of Bhopal in India.