| Jurisdiction: | Diocese |
| Debrecen–Nyíregyháza | |
| Latin: | Dioecesis Debrecenensis–Nyiregyhazanus |
| Local: | Debrecen-Nyíregyházi egyházmegye |
| Country: |  Hungary |
| Metropolitan: | Eger |
| Province: | Eger |
| Rite: | Latin Rite |
| Cathedral: | Cathedral of St Anne in Debrecen |
| Cocathedral: | Co-Cathedral of Our Lady of the Hungarians in Nyíregyháza |
| Area Km2: | 11,300 |
| Population: | 1,137,000 |
| Population As Of: | 2011 |
| Catholics: | 250,000 |
| Catholics Percent: | 22 |
| Metro Archbishop: | Csaba Ternyák |
| Map: | Ungheria - Diocesi di Debrecen-Nyiregyhaza.jpg |
| Map Size: | 250px |
| Coordinates: | 47.5262°N 21.6297°W |
| Headquarters: | Debrecen |
The Diocese of Debrecen–Nyíregyháza (Latin: Dioecesis Debrecenensis–Nyiregyhazanus) is a Latin Church diocese of the Catholic Church located in the cities of Debrecen and Nyíregyháza in the ecclesiastical province of Eger in Hungary.