| Jurisdiction: | Diocese |
| Cyangugu | |
| Latin: | Dioecesis Cyanguguensis |
| Country: |  Rwanda |
| Metropolitan: | Kigali |
| Rite: | Latin Rite |
| Area Km2: | 1.125 |
| Population: | 626,621 |
| Population As Of: | 2008 |
| Catholics: | 283,372 |
| Catholics Percent: | 45.22 |
| Bishop: | Edouard Sinayobye |
The Roman Catholic Diocese of Cyangugu (Latin: Cyanguguen(sis)) is a diocese located in the city of Cyangugu in the ecclesiastical province of Kigali in Rwanda. Since 2021, the Catholic Diocese of Cyangugu is entrusted to Bishop Edouard Sinayobye.
The Diocese of Cyangugu (in French Diocèse Catholique de Cyangugu) was established by Pope John Paul II on November 14, 1981. It was entrusted to Bishop Thaddeus Ntihinyurwa on January 24, 1982, as diocesan bishop until his appointment as Archbishop of Kigali on March 9, 1996, and as Apostolic Administrator of Cyangugu until January 2, 1997, when the pope appointed his successor, Bishop John Damascene Bimenyimana, who served as Bishop of the Diocese of Cyangugu until he died on March 11, 2018.