| Jurisdiction: | Diocese |
| Colón-Kuna Yala | |
| Latin: | Dioecesis Columbensis-Kunayalensis |
| Country: |  Panama |
| Metropolitan: | Jose Domingo Ulloa Mendieta, O.S.A. |
| Province: | Province of Panamá |
| Area Km2: | 8,167 |
| Population: | 237,019 |
| Population As Of: | 2006 |
| Catholics: | 171,000 |
| Catholics Percent: | 72.1 |
| Parishes: | 20 |
| Denomination: | Roman Catholic |
| Sui Iuris Church: | Latin Church |
| Rite: | Roman Rite |
| Established: | 15 December 1988 (years ago) |
| Cathedral: | Cathedral of the Immaculate Conception of Mary |
| Bishop Title: | Bishop |
| Bishop: | Manuel Ochogavía Barahona O.S.A |
| Emeritus Bishops: | Carlos María Ariz Bolea, C.M.F. |
| Map: | Panama - Diocesi di Colón-Kuna Yala.png |
The Roman Catholic Diocese of Colón-Kuna Yala (erected 15 December 1988 as the Diocese of Colón, renamed 13 June 1997) is a suffragan diocese of the Archdiocese of Panamá.