Roland Stocker Explained

Roland Stocker (born 5 October 1956 in Switzerland) is a Swiss Australian biochemist who discovered the antioxidant activity of bilirubin.[1] He is a former Olympic rower and has represented Switzerland at the 1980 Summer Olympics.[2]

Early life and education

Stocker was awarded a Diplom [im] Naturwissenschaften und Mathematik (Dipl. Natw.), or Diploma in/of Natural Science, from the ETH Zurich in 1981 and a Ph.D. from the Australian National University in 1985.[3]

Career

Stocker has made significant contributions to the understanding of the molecular action of Alpha-Tocopherol (vitamin E) during the oxidation of lipoproteins,[4] [5] the antioxidant activities of ubiquinol-10 in lipoproteins,[6] the contribution of oxidation of low-density lipoprotein to atherosclerosis,[7] the understanding of how antioxidants and heme oxygenase-1 protect against atherosclerosis,[8] [9] the role of myeloperoxidase to atherosclerotic plaque destabilization,[10] and the contribution of tryptophan metabolism by indoleamine 2,3-dioxygenase in the regulation of vascular tone in inflammation.[11] [12]

Stocker is recognized as a "redox pioneer".[13] He is a Fellow of the Swiss Academy of Medical Sciences and the Australian Academy of Health and Medical Sciences.

Formerly, Stocker held an appointment as a professor at the University of New South Wales and the University of Sydney, Australia. Currently, he is Group Leader at the Heart Research Institute.[14]

Personal life

Stocker lives in Sydney, Australia with his wife, Maree Stenglin.

Stocker's twin brother, Peter, was also an Olympic rower for Switzerland.

External links

Notes and References

  1. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN . Bilirubin is an antioxidant of possible physiological importance . Science . 235 . 1043–6 . 1987 . 10.1126/science.3029864 . 3029864 . 4792. 1987Sci...235.1043S .
  2. Web site: Roland Stocker Bio, Stats, and Results | Olympics at Sports-Reference.com. 18 April 2020. https://web.archive.org/web/20200418115216/https://www.sports-reference.com/olympics/athletes/st/roland-stocker-1.html. 18 April 2020.
  3. Web site: Research Supervisor Connect. The University of Sydney.
  4. Bowry VW, Ingold KU, Stocker R . Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant . Biochem J . 288 . 341–4 . 1992 . 2 . 1463440 . 1132016 . 10.1042/bj2880341.
  5. Ingold KU, Bowry VW, Stocker R, Walling C . Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein . Proc Natl Acad Sci U S A . 90 . 45–9 . 1993 . 10.1073/pnas.90.1.45 . 8419943 . 1 . 45596. 1993PNAS...90...45I . free .
  6. Stocker R, Bowry VW, Frei B . Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol . PNAS. 88 . 1646–50 . 1991 . 10.1073/pnas.88.5.1646 . 2000375 . 5 . 51081. 1991PNAS...88.1646S . free .
  7. Stocker R, Keaney JF Jr . Role of oxidative modifications in atherosclerosis . Physiol Rev . 84 . 1381–478 . 2004 . 10.1152/physrev.00047.2003 . 15383655 . 4.
  8. Wu BJ, Kathir K, Witting PK, Beck K, Choy K, Li C, Croft KD, Mori TA, Tanous D, Adams MR, Lau AK, Stocker R . Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging . J Exp Med . 203 . 1117–27 . 2006 . 10.1084/jem.20052321 . 16606673 . 4 . 2118288.
  9. Stocker R, Perrella MA . Heme oxygenase-1: a novel drug target for atherosclerotic diseases? . Circulation . 114 . 2178–89 . 2006 . 10.1161/CIRCULATIONAHA.105.598698 . 17101869 . 20. free .
  10. Rashid I, Maghzal GJ, Chen Y, Cheng D, Talib J, Newington D, Ren M, Vajandar SK, Searle A, Maluenda A, Lindstedt E, Jabbour A, Kettle AJ, Bongers A, Power C, Michaëlsson E, Peter K, Stocker R . Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque . Eur Heart J . 39 . 3301–10 . 2018 . 10.1093/eurheartj/ehy419 . 30219874 . 35 . 52281012 . free .
  11. Wang Y, Liu H, McKenzie G, Witting PK, Stasch JP, Hahn M, Changsirivathanathamrong D, Wu BJ, Ball HJ, Thomas SR, Kapoor V, Celermajer DS, Mellor AL, Keaney JF Jr, Hunt NH, Stocker R . Kynurenine is an endothelium-derived relaxing factor produced during inflammation . Nat Med . 16 . 279–85 . 2010 . 10.1038/nm.2092 . 20190767 . 3 . 3556275.
  12. Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y, Chadha P, Suarna C, Prysyazhna O, Scotcher J, Dunn LL, Prado FM, Nguyen N, Odiba JO, Baell JB, Stasch JP, Yamamoto Y, Di Mascio P, Eaton P, Payne RJ, Stocker R . Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation . Nature . 566 . 548–552 . 2019 . 10.1038/s41586-019-0947-3 . 30760924 . 7745. 2019Natur.566..548S . 1959.17/169229 . 61156683 .
  13. Hunt NH . Redox pioneer: professor Roland Stocker . Antioxid Redox Signal . 15 . 3101–5 . 2011 . 21609251 . 10.1089/ars.2010.3842 . 12.
  14. Web site: Arterial Inflammation and Redox Biology • Heart Research Institute. Heart Research Institute.

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