Rodrigo Ponce de Leon, Duke of Cádiz (1443–1492) was one of the Castilian military leaders in the conquest of Granada. In 1482, he led the Castilian forces that captured the town of Alhama and later Boabdil. He had earlier been one of the military leaders in the Castilian War of Succession. Juan Pacheco was his father-in-law. He was made 1st Duke of Cádiz in 1484 and succeeded briefly by his heir Francisca Ponce de León y de la Fuente.
Ponce de León is also related to:
Roderigo Ponce de Leon, marques of Cadiz is written about extensively in Washington Irving's 'Chronicle of the Conquest of Granada', published 1829.