| Country: | BRA |
| Alternate Name: | Rodovia Fernão Dias |
| Maint: | Autopista Fernão Dias (OHL) (since 2008) |
| Type: | BR |
| Route: | 381 |
| Image Alt: | Rodovia Fernão Dias |
| Image Notes: | The Fernão Dias highway near the border between the states of São Paulo and Minas Gerais. |
| Length Km: | 562.1 |
| Established: | 1959 (duplication made to a Dual carriageway in 2005) |
| Direction A: | North |
| Terminus A: | Avenida Cardeal Eugênio Pacelli in Contagem, MG |
| Direction B: | South |
| Terminus B: | Avenida Educador Paulo Freire in Vila Maria, São Paulo, SP |
The Rodovia Fernão Dias (official designation BR-381 or SP-010 in the state of São Paulo) is a federal highway which runs in the Brazilian states of São Paulo and southern region of Minas Gerais. In Atibaia, the Fernão Dias highway intersects the Dom Pedro I highway, which runs from Campinas to Jacareí.
The highway is thus named in honour of Fernão Dias Paes Leme, a Brazilian explorer and "bandeirante" of the 17th century. It is 562.1 km long. It was fully duplicated in 2002.[1]
Note: All squares are bidirectional.