Roche ester explained

Roche ester (methyl 3-hydroxy-2-methylpropionate) is a chemical compound with formula C5H10O3. It can exist as two enantiomers. Both are commercially available and have been widely used as starting blocks for the synthesis of many targets including dictyostatin,[1] discodermolide[2] and spongidepsin.[3]

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Notes and References

  1. Shin . Youseung . Fournier. Jean-Hugues. Fukui. Yoshikazu. Brückner. Arndt. Curran. Dennis. Dennis Patrick Curran . 2004 . Total Synthesis of (−)-Dictyostatin: Confirmation of Relative and Absolute Configurations. Angewandte Chemie International Edition. 43. 35. 4634–4637. Wiley. 10.1002/anie.200460593 . 15316999.
  2. Paterson . Ian . Florence. Gordon. 2003 . The Development of a Practical Total Synthesis of Discodermolide, a Promising Microtubule-Stabilizing Anticancer Agent. European Journal of Organic Chemistry. 2003. 12. 2193–2208. Wiley. 10.1002/ejoc.200300061 .
  3. Ferrié. Laurent. Reymond. Sébastien. Capdevielle. Patrice. Cossy. Janine. 2006 . Total Synthesis of (−)-Spongidepsin. Organic Letters. 8. 16. 3441–3443. American Chemical Society. 10.1021/ol061029w . 16869630.

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