Roberto Ferrari (cardiologist) explained

Roberto Ferrari
Birth Date:10 June 1950
Occupation:Cardiologist

Roberto Ferrari (born 10 June 1950) is an Italian cardiologist who holds the position of Emeritus Professor at the University of Ferrara,[1] [2] [3] where besides he was the chair of the Cardiology in the School of Medicine until the 2019–2020 academic year.

Ferrari has served as the Director of the Cardiovascular Centre of the University of Ferrara, the Director of Cardiology at the St. Anna University Hospital of Ferrara, and the Director of the Centre of Cardiovascular Research "S. Maugeri".[4] Ferrari is past President of the European Society of Cardiology (ESC).

Life

Ferrari was born in La Spezia, Italy. He is the only son of a textile merchant. He was encouraged by his cousin, a biochemist, Anna Maria Sechi, to study medicine.[5] [6] [7]

Education

Ferrari graduated with distinction from the Bologna School[8] of Medicine in 1974.[9] [10] Upon graduation, Professor Ferrari went on to complete specialized post graduate studies at both the School of Cardiology through the University of Parma (1974-1976), and the School of Radiology through the University of Bologna (1977-1980). Driven by a keen interest in research, Professor Ferrari proceeded to complete his PhD degree in field of cardiac metabolism at the Cardiothoracic Institute of the National Heart Hospital through the University of London (1980-1982). He served as an Honorary Assistant Research Fellow at the National Heart Hospital in London from 1978 to 1989, and as a Senior Research Fellow at the Rayne Institute of St. Thomas’ Hospital in London (1989-1996).

Career

Ferrari has contributed scientific findings targeted at characterizing the molecular mechanisms of the ischemic and failing myocardium, dedicating himself to improving the clinical treatment of myocardial ischemia and heart failure, while placing a particular emphasis on interdisciplinary and collaborative studies throughout his career.

Ferrari holds the position of Emeritus Professor at the University of Ferrara. His academic career path development follows his initial appointment to the position of associate professor in Cardiology at the University of Brescia in 1987 and then at the University of Ferrara in 1998. In 2000, Professor Ferrari was appointed to the position of Full Professor in Cardiology as well as the Director of the Cardiovascular Centre of the University of Ferrara and Director of Cardiology at the St. Anna University Hospital of Ferrara. In addition to his current position as Emeritus Professor, Ferrari is presently the Scientific Director of Medical Trial Analysis, an academic Clinical Research Organization (CRO).[11] He founded the European Heart for Children (EHC), established during his presidency of the European Society of Cardiology (ESC). As a non-profit organization, the EHC aims to cure children born with congenital heart diseases in underdeveloped countries. Since its formation, the EHC has effectively conducted nearly 30 missions, examined, diagnosed, and treated over 2200 children, with 349 being successfully operated on, and trained numerous cardiologists and cardiac surgeons around the world. Moreover, the EHC has built a pediatric cardiovascular surgeon training center in Nigeria and successfully constructed a Pediatric Unit in Syria, with the third facility in Morocco currently in progress.[12] [13] [14]

Ferrari has held positions held in several cardiological organizations: Founder and President of the European Heart for Children (EHC) from 2010 to 2018; Member of the European Society of Cardiology (ESC) Committee for Practice Guidelines from 2012 to 2014;[15] President of the European Society of Cardiology (ESC) from 2008 to 2010;[16] [4] Vice President & Chairman of the ESC Associations, Councils & Working Groups 2004–2006; Executive Board Member and Chairman of the ESC Education Committee 2002–2004; President of the World Section of the International Society for Heart Research (ISHR) from 2004 to 2007 and Treasurer from 1994 to 2002.[17] He was Chairman of the ESC Working Group on Cellular Biology 1994–1996, Chairman of the EURObservational Research Program (EORP) of the European Society of Cardiology,[18] Director of the School for Clinical and Epidemiologic Researchers, Board member of the World Heart Federation as a representative of Italy[19] and founder and president of the scientific foundation Fondazione Anna Maria Sechi per il Cuore (FASC) in honor of his cousin.[20] [21]

Editorial boards

He is Editor-in-Chief of the European Heart Journal Supplements: the Heart of the Matter[22] [23] and Editor of Dialogues in Cardiovascular Medicine.

His contributions to the field of cardiology include several books, over 800 published peer-reviewed papers, citation numbers nearing 50 000, and an H-index that is close to 90.[24] [25] [26]

Honors and awards

Scientific contributions

Ferrari's scientific contributions are recognized in both the field of basic and translational medicine, as well as clinical research. Ferrari's extensive research contributions have led to significant changes in cardiology practice guidelines and resulted in the successful registration of related pharmaceutical products.[30] [31]

Translational medicine

Ferrari's contributions in basic and Medicina traslazionale encompass 4 distinct areas:

Clinical medicine

Ferrari's contributions in clinical medicine have led to changes in cardiology practice guidelines and facilitated the registration of pharmaceutical products in 5 distinct areas:

Steering committees

Ferrari has been on the steering committees of several multicenter trials as chairman of the following trials: PREAMI, EUROPA, STRATEGY, MULTI-STRATEGY, 3T2R, Beautiful, Shift, Signify, Modify, START-IF, ATPCI. And as the Executive Committee Member of the following trials: SENIORS, PACMAN, Clarify, COMPOSE, RELAX-AHF 2.

Bibliography

Notes and References

  1. Web site: Cerimonie Unife celebra i suoi Professori Emeriti e Onorari . 2022-07-01 . Università degli studi di Ferrara . it.
  2. Web site: 6th Iranian Joint Cardiovascular Congress - Roberto FERRARI . 2022-07-01 . 2018ijcc.iha.org.ir.
  3. Web site: Cardiology & Diabetes 2010 Speaker biographies . 2022-07-01 . The Lancet. 10.1016/presentation.2014.12.08.1218 . 31 January 2024 .
  4. Web site: HealthManagement.org . Radiology Management, ICU Management, Healthcare IT, Cardiology Management, Executive Management . 2022-07-01 . HealthManagement . en.
  5. Kirby . Tony . August 2010 . Roberto Ferrari: outgoing ESC President and dynamic cardiologist . The Lancet . 376 . 9740 . 507 . 10.1016/s0140-6736(10)61240-8 . 0140-6736 . 20709220 . 36881267.
  6. Web site: Publishing . BIBA . 2011-04-17 . Roberto Ferrari . 2022-07-01 . Cardiovascular News . en-GB.
  7. Ozkan . Judy . 2020-12-14 . Roberto Ferrari . European Heart Journal . en . 41 . 47 . 4463–4465 . 10.1093/eurheartj/ehaa903 . 33128059 . 0195-668X. free .
  8. https://www.unibo.it/it Bologna School
  9. Lüscher . Thomas F. . March 2009 . CardioPulse: sensing the cardiovascular world . European Heart Journal . 30 . 5 . 517–523 . 10.1093/eurheartj/ehp059 . 1522-9645 . 19252223.
  10. 2010-09-01 . CardioPulse Articles . European Heart Journal . en . 31 . 17 . 2067–2074 . 10.1093/eurheartj/ehq260 . 0195-668X.
  11. Web site: MTA - Medical Trials Analysis - Contract Research Organization (CRO) . 2022-07-01 . MTA - Medical Trials Analysis - Contract Research Organization (CRO) . en.
  12. July 2010 . CardioPulse Articles . European Heart Journal . en . 31 . 14 . 1663–1671 . 10.1093/eurheartj/ehq191 . 20630896 . 1522-9645. MacDonald . I. . Pasupati . S. . free .
  13. Web site: Home . 2022-07-01 . www.europeanheartforchildren.com.
  14. Ferrari . Roberto . Frigiola . Alessandro . 2018-10-01 . Are all children born the same? . European Heart Journal . en . 39 . 37 . 3411–3415 . 10.1093/eurheartj/ehy489 . 30102346 . 0195-668X. free . 11392/2411180 . free .
  15. Web site: ESC Clinical Practice Guidelines Committee (CPG Committee) . 2022-07-01 . www.escardio.org.
  16. Web site: A brief history of the ESC . 2022-07-01 . www.escardio.org.
  17. Web site: ISHR Presidents Gallery . 2022-07-04.
  18. Web site: Past Presidents' Committee . 2022-07-04 . www.escardio.org.
  19. Web site: World Heart Federation Annual Report 2011 . 2022-07-04.
  20. Web site: Ridere protegge cuore come sport e farmaci . 2022-07-04 . www.pharmapro.ch.
  21. Web site: NASCE LA FONDAZIONE "ANNA MARIA SECHI PER IL CUORE" – Medinews . 2022-07-04 . it-IT.
  22. Web site: European Heart Journal Supplements Oxford Academic . 2022-07-04 . OUP Academic . en.
  23. Web site: EHJ Supplements . www.escardio.org.
  24. Web site: ORCID . 2022-07-04 . orcid.org.
  25. Web site: Scopus preview - Ferrari, Roberto - Author details - Scopus . 2022-07-04 . www.scopus.com.
  26. Web site: Top Italian Scientists . 2022-07-04 . topitalianscientists.org.
  27. 2013-02-14 . CardioPulse Articles . European Heart Journal . 34 . 7 . 477–482 . 10.1093/eurheartj/ehs430 . 0195-668X. free .
  28. Web site: ESC 365 - The cardiology knowledge hub . 2022-07-04 . esc365.escardio.org . en.
  29. Web site: National Heart Failure Societies Summit Programme. 2022 . 2022-07-04.
  30. Endorsed by the European Society of Intensive Care Medicine . 2005-01-25 . Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: The Task Force on Acute Heart Failure of the European Society of Cardiology . European Heart Journal . en . 26 . 4 . 384–416 . 10.1093/eurheartj/ehi044 . 15681577 . 0195-668X. free . 10400.16/493 . free .
  31. Authors/Task Force Members . Konstantinides . Stavros V. . Torbicki . Adam . Agnelli . Giancarlo . Danchin . Nicolas . Fitzmaurice . David . Galiè . Nazzareno . Gibbs . J. Simon R. . Huisman . Menno V. . Humbert . Marc . Kucher . Nils . 2014-11-14 . 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism . European Heart Journal . en . 35 . 43 . 3033–3080 . 10.1093/eurheartj/ehu283 . 25173341 . 1522-9645. free .
  32. Ananad . I.S. . Veall . N. . Kalra . G.S. . Ferrari . R. . Sutton . G. . Lipkin . D. . Harris . P. . Poole-Wilson . P.A. . 1989-05-01 . Treatment of heart failure with diuretics: body compartments, renal function and plasma hormones . European Heart Journal . en . 10 . 5 . 445–450 . 10.1093/oxfordjournals.eurheartj.a059508 . 2668005 . 1522-9645.
  33. Anand . I S . Ferrari . R . Kalra . G S . Wahi . P L . Poole-Wilson . P A . Harris . P C . 1989-08-01 . Edema of cardiac origin. Studies of body water and sodium, renal function, hemodynamic indexes, and plasma hormones in untreated congestive cardiac failure. . Circulation . en . 80 . 2 . 299–305 . 10.1161/01.CIR.80.2.299 . 2752558 . 0009-7322. free .
  34. Agnoletti . G. . Panzali . A. F. . Cornacchiari . A. . De Giuli . F. . Ferrari . R. . Sep 1990 . Effects of prolonged infusions of atrial natriuretic peptide and isoproterenol on the mechanical and endocrine function of isolated atria . Cardioscience . 1 . 3 . 217–223 . 1015-5007 . 2151714.
  35. Anand . Inder S. . Gurden . Jane . Wander . Gurpreet S. . O'Gara . Peter . Harding . Sian E. . Ferrari . Roberto . Cornacchiari . A. . Panzali . A. . Wahi . Purshotam L. . Poole-Wilson . Philip A. . Jan 1991 . Cardiovascular and hormonal effects of calcitonin gene-related peptide in congestive heart failure . Journal of the American College of Cardiology . en . 17 . 1 . 208–217 . 10.1016/0735-1097(91)90729-S. 1987228 . 29615207 . free .
  36. Curello . S . Ceconi . C . Degiuli . F . Cargnoni . A . Alfieri . O . Pardini . A . Marzollo . P . Mastropiero . R . Ferrari . R . 1991 . Time course of human atrial natriuretic factor release during cardiopulmonary bypass in mitral valve and coronary artery diseased patients . European Journal of Cardio-Thoracic Surgery . en . 5 . 4 . 205–210 . 10.1016/1010-7940(91)90031-E. 1829375 .
  37. Anand . I S . Ferrari . R . Kalra . G S . Wahi . P L . Poole-Wilson . P A . Harris . P C . Jun 1991 . Pathogenesis of edema in constrictive pericarditis. Studies of body water and sodium, renal function, hemodynamics, and plasma hormones before and after pericardiectomy. . Circulation . en . 83 . 6 . 1880–1887 . 10.1161/01.CIR.83.6.1880 . 2040040 . 1872909 . 0009-7322. free .
  38. Ferrari . R. . Panzali . A.F. . Poole-Wilson . P.A. . Anand . S. . Oct 1991 . Plasma CGRP-like immunoreactivity in treated and untreated congestive heart failure . The Lancet . en . 338 . 8774 . 1084 . 10.1016/0140-6736(91)91944-P. 1681388 . 33395755 .
  39. Mantri . R. R. . Bajaj . R. . Radhakrishnan . S. . Sinha . N. . Bidwai . P. S. . Apr 1992 . Pathogenesis of edema in constrictive pericarditis . Circulation . 85 . 4 . 1634–1635 . 10.1161/circ.85.4.1555304 . 0009-7322 . 1555304. free .
  40. Anand . I S . Chandrashekhar . Y . Ferrari . R . Sarma . R . Guleria . R . Jindal . S K . Wahi . P L . Poole-Wilson . P A . Harris . P . Jul 1992 . Pathogenesis of congestive state in chronic obstructive pulmonary disease. Studies of body water and sodium, renal function, hemodynamics, and plasma hormones during edema and after recovery. . Circulation . en . 86 . 1 . 12–21 . 10.1161/01.CIR.86.1.12 . 1617764 . 52868499 . 0009-7322. free .
  41. Ferrari . R. . La Canna . G. . Giubbini . R. . Alfieri . O. . Visioli . O. . Jun 1992 . Hibernating myocardium in patients with coronary artery disease: Identification and clinical importance . Cardiovascular Drugs and Therapy . en . 6 . 3 . 287–293 . 10.1007/BF00051152 . 1637735 . 3046148 . 0920-3206.
  42. Ferrari . R. . La Canna . G. . Giubbini . R. . Visioli . O. . 1992 . Stunned and hibernating myocardium: possibility of intervention . Journal of Cardiovascular Pharmacology . 20 . Suppl 5 . S5–13 . 10.1097/00005344-199212061-00002 . 0160-2446 . 1282614.
  43. La Canna . Giovanni . Alfieri . Ottavio . Giubbini . Rafaele . Gargano . Mario . Ferrari . Roberto . Visioli . Odoardo . Mar 1994 . Echocardiography during infusion of dobutamine for identification of reversible dyfunction in patients with chronic coronary artery disease . Journal of the American College of Cardiology . en . 23 . 3 . 617–626 . 10.1016/0735-1097(94)90745-5. 8113543 . free .
  44. Dejong . J . Cargnomi . A . Bradamante . S . Curello . S . Janssen . M . Pasini . E . Ceconi . C . Bunger . R . Ferrari . R . Jan 1995 . Intermittent v continuous ischernia decelerates adenylate breakdown and prevents norepinephrine release in reperfused rabbit heart . Journal of Molecular and Cellular Cardiology . en . 27 . 1 . 659–671 . 10.1016/S0022-2828(08)80058-2. 7760385 .
  45. Ferrari . R. . Cargnoni . A. . Bernocchi . P. . Pasini . E. . Curello . S. . Ceconi . C. . Ruigrok . T.J.C. . 1996-11-15 . Metabolic Adaptation During a Sequence of No-Flow and Low-Flow Ischemia: A Possible Trigger for Hibernation . Circulation . en . 94 . 10 . 2587–2596 . 10.1161/01.CIR.94.10.2587 . 8921805 . 0009-7322.
  46. Ferrari . R. . Ferrari . F. . Benigno . M. . Pepi . P. . Visioli . O. . Sep 1998 . Hibernating myocardium: its pathophysiology and clinical role . Molecular and Cellular Biochemistry . 186 . 1–2 . 195–199 . 10.1023/A:1006872827169 . 0300-8177 . 9774201. 37210796 .
  47. Ferrari . Robert . 1999 . The search for the hibernating myocardium--have we reached the limit? . Cardiovascular Drugs and Therapy . 13 . 2 . 137–143 . 10.1023/A:1007788210163. 10372229 . 30606224 .
  48. LaCanna . G . 2000-08-15 . Sensitivity, specificity, and predictive accuracies of non-invasive tests, singly and in combination, for diagnosis of hibernating myocardium . European Heart Journal . en . 21 . 16 . 1358–1367 . 10.1053/euhj.1999.2038. 10952825 . free .
  49. Rahimtoola . Shahbudin H. . La Canna . Giovanni . Ferrari . Roberto . Mar 2006 . Hibernating Myocardium . Journal of the American College of Cardiology . en . 47 . 5 . 978–980 . 10.1016/j.jacc.2005.11.038. 16516080 . 43552227 . free .
  50. Ferrari . R. . Ceconi . C. . Pertinent: Authors' Retrospective . 2012-11-01 . Cardiovascular Research . en . 96 . 2 . 204–207 . 10.1093/cvr/cvs165 . 0008-6363. free .
  51. Ferrari . R . 2001-05-15 . Favouring myocardial viability to necrosis: a challenge in ischaemic heart disease with prognostic complications . European Heart Journal . en . 22 . 10 . 803–804 . 10.1053/euhj.2000.2563. 11350086 . free .
  52. Scarabelli . Tiziano . Stephanou . Anastasis . Rayment . Neil . Pasini . Evasio . Comini . Laura . Curello . Salvatore . Ferrari . Roberto . Knight . Richard . Latchman . David . 2001-07-17 . Apoptosis of Endothelial Cells Precedes Myocyte Cell Apoptosis in Ischemia/Reperfusion Injury . Circulation . en . 104 . 3 . 253–256 . 10.1161/01.CIR.104.3.253 . 11457740 . 6661375 . 0009-7322. free .
  53. Ferrari . R . 2002-01-01 . Interleukin-6: a neurohumoral predictor of prognosis in patients with heart failure: light and shadow . European Heart Journal . en . 23 . 1 . 9–10 . 10.1053/euhj.2001.3060. 11741356 . free .
  54. Valgimigli . Marco . Agnoletti . Laura . Curello . Salvatore . Comini . Laura . Francolini . Gloria . Mastrorilli . Francesca . Merli . Elisa . Pirani . Roberto . Guardigli . Gabriele . Grigolato . Pier Giovanni . Ferrari . Roberto . 2003-01-21 . Serum From Patients With Acute Coronary Syndromes Displays a Proapoptotic Effect on Human Endothelial Cells: A Possible Link to Pan-Coronary Syndromes . Circulation . en . 107 . 2 . 264–270 . 10.1161/01.CIR.0000045665.57256.86 . 12538426 . 6804985 . 0009-7322. free .
  55. EUROPA-PERTINENT Investigators . 2003 . PERTINENT--perindopril-thrombosis, inflammation, endothelial dysfunction and neurohormonal activation trial: a sub-study of the EUROPA study . Cardiovascular Drugs and Therapy . 17 . 1 . 83–91 . 10.1023/A:1024394610648. 12843690 . 23888783 .
  56. Valgimigli . Marco . Ceconi . Claudio . Malagutti . Patrizia . Merli . Elisa . Soukhomovskaia . Olga . Francolini . Gloria . Cicchitelli . Giordano . Olivares . Adriana . Parrinello . Giovanni . Percoco . Gianfranco . Guardigli . Gabriele . 2005-02-22 . Tumor Necrosis Factor-α Receptor 1 Is a Major Predictor of Mortality and New-Onset Heart Failure in Patients With Acute Myocardial Infarction: The Cytokine-Activation and Long-Term Prognosis in Myocardial Infarction (C-ALPHA) Study . Circulation . en . 111 . 7 . 863–870 . 10.1161/01.CIR.0000155614.35441.69 . 15699251 . 7710874 . 0009-7322. free .
  57. Ceconi . C . Fox . K . Remme . W . Simoons . M . Bertrand . M . Parrinello . G . Kluft . C . Blann . A . Cokkinos . D . Ferrari . R . 2007-01-01 . ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT . Cardiovascular Research . en . 73 . 1 . 237–246 . 10.1016/j.cardiores.2006.10.021. 17140552 . 2783663 .
  58. Angelini . Annalisa . Maiolino . Giuseppe . La Canna . Giovanni . Ceconi . Claudio . Calabrese . Fiorella . Pettenazzo . Elena . Valente . Marialuisa . Alfieri . Ottavio . Thiene . Gaetano . Ferrari . Roberto . Apr 2007 . Relevance of apoptosis in influencing recovery of hibernating myocardium . European Journal of Heart Failure . en . 9 . 4 . 377–383 . 10.1016/j.ejheart.2006.09.012. 17127093 . 27926887 .
  59. Ferrari . Roberto . Bertrand . Michel E . Remme . Willem J . Simoons . Maarten L . Deckers . Jaap W . Fox . Kim M . Nov 2007 . Insight into ACE inhibition in the prevention of cardiac events in stable coronary artery disease: the EUROPA trial . Expert Review of Cardiovascular Therapy . en . 5 . 6 . 1037–1046 . 10.1586/14779072.5.6.1037 . 18035919 . 43723509 . 1477-9072.
  60. Ceconi . Claudio . Fox . Kim M. . Remme . William J. . Simoons . Maarten L. . Deckers . Jaap W. . Bertrand . Michel . Parrinello . Giovanni . Kluft . Cornelius . Blann . Andrew . Cokkinos . Dennis . Ferrari . Roberto . May 2009 . ACE inhibition with perindopril and biomarkers of atherosclerosis and thrombosis: Results from the PERTINENT study . Atherosclerosis . en . 204 . 1 . 273–275 . 10.1016/j.atherosclerosis.2008.08.042. 18950770 .
  61. Ferrari . Roberto . Ceconi . Claudio . Campo . Gianluca . Cangiano . Elisa . Cavazza . Caterina . Secchiero . Paola . Tavazzi . Luigi . 2009 . Mechanisms of Remodelling A Question of Life (Stem Cell Production) and Death (Myocyte Apoptosis): A Question of Life (Stem Cell Production) and Death (Myocyte Apoptosis) . Circulation Journal . en . 73 . 11 . 1973–1982 . 10.1253/circj.CJ-09-0573 . 19822975 . 84309718 . 1346-9843. free .
  62. Caliceti . C. . Nigro . P. . Rizzo . P. . Ferrari . R. . 2014 . ROS, Notch, and Wnt Signaling Pathways: Crosstalk between Three Major Regulators of Cardiovascular Biology . BioMed Research International . en . 2014 . 318714 . 10.1155/2014/318714 . 2314-6133 . 3932294 . 24689035. free .
  63. Ferrari . R. . Rizzo . P. . 2014-08-02 . The Notch pathway: a novel target for myocardial remodelling therapy? . European Heart Journal . en . 35 . 32 . 2140–2145 . 10.1093/eurheartj/ehu244 . 24970336 . 0195-668X. free .
  64. Rizzo . Paola . Mele . Donato . Caliceti . Cristiana . Pannella . Micaela . Fortini . Cinzia . Clementz . Anthony George . Morelli . Marco Bruno . Aquila . Giorgio . Ameri . Pietro . Ferrari . Roberto . 2015-01-13 . The Role of Notch in the Cardiovascular System: Potential Adverse Effects of Investigational Notch Inhibitors . Frontiers in Oncology . 4 . 384 . 10.3389/fonc.2014.00384 . 2234-943X . 4292456 . 25629006. free .
  65. Rizzo . P. . Ferrari . R. . 2015-03-01 . The Notch pathway: a new therapeutic target in atherosclerosis? . European Heart Journal Supplements . en . 17 . suppl A . A74–A76 . 10.1093/eurheartj/suv011 . 1520-765X. free .
  66. Ferrari . Roberto . Malagù . M. . Biscaglia . S. . Fucili . A. . Rizzo . P. . 2016 . Remodelling after an Infarct: Crosstalk between Life and Death . Cardiology . en . 135 . 2 . 68–76 . 10.1159/000445882 . 27270988 . 40446194 . 0008-6312. free .
  67. Sep 2003 . Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study) . The Lancet . en . 362 . 9386 . 782–788 . 10.1016/S0140-6736(03)14286-9. 13678872 . 25149680 . Fox . K. M. .
  68. Ferrari . Roberto . Fox . Kim . 2009 . Insight into the Mode of Action of ACE Inhibition in Coronary Artery Disease: The Ultimate 'EUROPA' Story . Drugs . en . 69 . 3 . 265–277 . 10.2165/00003495-200969030-00003 . 19275271 . 39598433 . 0012-6667.
  69. European trial on reduction of cardiac events with perindopril in stable coronary artery disease - EUROPA . American College of Cardiology.
  70. Fox . Kim . Ferrari . Roberto . Tendera . Michal . Steg . Philippe Gabriel . Ford . Ian . Nov 2006 . Rationale and design of a randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction: the morBidity-mortality EvAlUaTion of the If inhibitor ivabradine in patients with coronary disease and left ventricULar dysfunction (BEAUTIFUL) Study . American Heart Journal . en . 152 . 5 . 860–866 . 10.1016/j.ahj.2006.01.013. 17070146 .
  71. Fox . Kim . Ford . Ian . Steg . P Gabriel . Tendera . Michal . Ferrari . Roberto . Sep 2008 . Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial . The Lancet . en . 372 . 9641 . 807–816 . 10.1016/S0140-6736(08)61170-8. 18757088 . 26282333 .
  72. Fox . Kim . Ford . Ian . Steg . P Gabriel . Tendera . Michal . Robertson . Michele . Ferrari . Roberto . Sep 2008 . Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial . The Lancet . en . 372 . 9641 . 817–821 . 10.1016/S0140-6736(08)61171-X. 18757091 . 6481363 .
  73. Fox . K. . Ford . I. . Steg . Ph. G. . Tendera . M. . Robertson . M. . Ferrari . R. . on behalf of the BEAUTIFUL Investigators . 2009-10-01 . Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial . European Heart Journal . en . 30 . 19 . 2337–2345 . 10.1093/eurheartj/ehp358 . 19720635 . 0195-668X. free .
  74. Swedberg . Karl . Komajda . Michel . Böhm . Michael . Borer . Jeffrey S . Ford . Ian . Dubost-Brama . Ariane . Lerebours . Guy . Tavazzi . Luigi . Sep 2010 . Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study . The Lancet . en . 376 . 9744 . 875–885 . 10.1016/S0140-6736(10)61198-1. 20801500 . 21196422 .
  75. Böhm . Michael . Swedberg . Karl . Komajda . Michel . Borer . Jeffrey S . Ford . Ian . Dubost-Brama . Ariane . Lerebours . Guy . Tavazzi . Luigi . Sep 2010 . Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial . The Lancet . en . 376 . 9744 . 886–894 . 10.1016/S0140-6736(10)61259-7. 20801495 . 205959868 .
  76. Writing Committee . Smith . S. C. . Collins . A. . Ferrari . R. . Holmes . D. R. . Logstrup . S. . McGhie . D. V. . Ralston . J. . Sacco . R. L. . Stam . H. . Taubert . K. . 2012-12-01 . Our time: a call to save preventable death from cardiovascular disease (heart disease and stroke) . European Heart Journal . en . 33 . 23 . 2910–2916 . 10.1093/eurheartj/ehs313 . 22988314 . 0195-668X. free .
  77. Rizzo . Paola . Miele . Lucio . Ferrari . Roberto . 2013-08-21 . The Notch pathway: a crossroad between the life and death of the endothelium . European Heart Journal . en . 34 . 32 . 2504–2509 . 10.1093/eurheartj/ehs141 . 22645188 . 1522-9645. free .
  78. Fox . Kim M. . Ferrari . Roberto . Jul 2011 . Heart rate: a forgotten link in coronary artery disease? . Nature Reviews Cardiology . en . 8 . 7 . 369–379 . 10.1038/nrcardio.2011.58 . 21519356 . 20523105 . 1759-5002.
  79. Fox . Kim . Ford . Ian . Steg . Philippe Gabriel . Tardif . Jean-Claude . Tendera . Michal . Ferrari . Roberto . Oct 2013 . Rationale, design, and baseline characteristics of the Study assessInG the morbidity-mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease (SIGNIFY trial): A randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease without clinical heart failure . American Heart Journal . en . 166 . 4 . 654–661.e6 . 10.1016/j.ahj.2013.06.024. 24093844 .
  80. Fox . Kim . Ford . Ian . Steg . Philippe Gabriel . Tardif . Jean-Claude . Tendera . Michal . Ferrari . Roberto . SIGNIFY Investigators . 2014-09-18 . Ivabradine in stable coronary artery disease without clinical heart failure . The New England Journal of Medicine . 371 . 12 . 1091–1099 . 10.1056/NEJMoa1406430 . 1533-4406 . 25176136. 19002896 . free . 20.500.11820/d9aed159-0654-4fa1-a6d9-8c5fb6dd325a . free .
  81. Fox . Kim . Ford . Ian . Steg . Philippe Gabriel . Tardif . Jean-Claude . Tendera . Michal . Ferrari . Roberto . 2015-09-17 . Bradycardia and atrial fibrillation in patients with stable coronary artery disease treated with ivabradine: an analysis from the SIGNIFY study . European Heart Journal . 36 . 46 . en . 3291–3296 . 10.1093/eurheartj/ehv451 . 26385957 . 0195-668X. free . 11392/2349608 . free .
  82. Ferrari . Roberto . Ford . Ian . Fox . Kim . Challeton . Jean Pascal . Correges . Anne . Tendera . Michal . Widimský . Petr . Danchin . Nicolas . Sep 2020 . Efficacy and safety of trimetazidine after percutaneous coronary intervention (ATPCI): a randomised, double-blind, placebo-controlled trial . The Lancet . en . 396 . 10254 . 830–838 . 10.1016/S0140-6736(20)31790-6. 32877651 . 221365071 . 10044/1/82242 . free .

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