Robert Roskoski Explained

Robert Roskoski Jr.
Workplaces:	Blue Ridge Institute for Medical Research
Alma Mater:	Bowling Green State University University of Chicago Rockefeller University

Robert Roskoski Jr. is the Scientific Director and President of the Blue Ridge Institute for Medical Research.

Education

Roskoski studied chemistry at Bowling Green State University, receiving a B.S. degree in 1961. He received an M.D. in 1964 and a Ph.D. in 1968 from the University of Chicago. His doctoral adviser was Donald F. Steiner, the discoverer of proinsulin.^[1] Roskoski was in the medical corps of the United States Air Force. Later, He became a Senior Investigator at the U.S. Air Force School of Aerospace Medicine at Brooks Air Force Base in San Antonio. He subsequently performed postdoctoral studies at the Rockefeller University under the tutelage of Fritz Lipmann from 1969 to 1972.^[2]

Research and career

Robert Roskoski did research on the classification of small molecule protein kinase inhibitors that are used in the treatment of several cancers and he also developed the Gold Standard procedure for the measurement of Protein Kinase Enzyme Activity.^[3] His research interests include Protein kinase structure and function, Cancer chemotherapy,^[4] and Signal transduction.

He studied protein kinase structure and function and signal transduction. He also founded the Blue Ridge Institute for Medical Research in Horse Shoe, North Carolina in 2006. Research at the institute focuses on FDA-approved protein kinase inhibitors and monitoring extramural NIH grant support.^[5]

Awards and honors

Robert Roskoski received the NIH Postdoctoral membership and NIH Special postdoctoral membership. From 1991 to 2006, he was the Fred G. Brazda Professor of Biochemistry at LSU Health Sciences Center in New Orleans.^[6]

American Chemical Society honors^[7]

Publications

• Roskoski R Jr. (1983) Assays of protein kinase. Methods in Enzymology 99, 3–6.
• Roskoski R Jr. (2005) Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys. Res. Commun. 331, 1–14.
• Roskoski R Jr. (2007) Vascular endothelial growth factor (VEGF) signalling in tumor progression. Crit. Rev. Oncol. Hematol. 62, 179–213.
• Roskoski R Jr. (2012) ERK1/2 MAP kinases: Structure, function, and regulation. Pharmacol. Res. 66, 105–143.
• Roskoski R Jr. (2014) The ErbB/HER family of protein-tyrosine kinases and cancer. Pharmacol. Res. 79, 34–74.
• Roskoski R Jr. A historical overview of protein kinases and their targeted small molecule inhibitors. Pharmacol Res 2015;100:1–23.
• Roskoski R Jr. (2016) Classification of small molecule inhibitors based upon the structures of their drug enzyme complexes. Pharmacol. Res. 103, 26–48.

Notes and References

1. Polonsky. Kenneth S.. Rubenstein. Arthur H.. 2015. Donald F. Steiner, MD, 1930–2014. Diabetologia. 58. 3. 419–421. 10.1007/s00125-015-3495-x. 0012-186X. 4320298. 25617020.
2. Web site: Fritz Lipmann, Hans Krebs, Francis Crick, Robert Roskoski Jr., Rockefeller University, Photos. 2022-01-05. Blue Ridge Institute for Medical Research.
3. Web site: A Retired Professor's Research Rankings Get Universities' Attention . The Chronicle of Higher Education . en . 25 March 2012.
4. Web site: Barbanel . Josh . Medical Schools Jockey for Research Space . Wall Street Journal . 13 December 2012.
5. Web site: Robert Roskoski Jr. MD, PhD. 2022-01-05. Blue Ridge Institute for Medical Research.
6. Web site: LSU. Members of the 500 Club, which supports basic science professorships.
7. Web site: ACS honors its 50-year members . American Chemical Society.