| Robert A. Lamb | |
| Birth Date: | 26 September 1950 |
| Birth Place: | Muswell Hill, London, England |
| Nationality: | British American |
| Kenneth F. Burgess Professor | |
| Doctoral Advisor: | Brian Mahy |
| Workplaces: | Northwestern University |
| Alma Mater: | University of Birmingham (B.Sc., 1971) University of Cambridge (Ph.D., 1974) |
Robert A. Lamb (September 26, 1950 – September 2, 2023) was a British-American virologist. He was the Kenneth F. Burgess Professor at Northwestern University and since 1991, an investigator of the Howard Hughes Medical Institute. From 1990 to 2016, he was the John Evans Professor of Molecular and Cellular Biology at Northwestern University.
Lamb's research focused on influenza and paramyxoviruses. His work on mechanism of action of viral proteins has had a significant impact on the field of virology.[1] His research in this area has led to the development of new vaccines and medicines. Lamb has also done considerable research on how cells work.[2]
For his contributions to the field of virology, Lamb has won several awards. In 1990, he was awarded the Wallace P. Rowe Award for Excellence in Virology Research.[3] In 2003, he was elected to the National Academy of Sciences and in 2010, the University of Birmingham awarded him an Sc.D. honoris causa. He also won consecutive MERIT awards from the National Institutes of Health 1987-2006 and 2007-2016.[4]
Lamb was born on September 26, 1950, in Muswell Hill, London. His uncle was a chemist, who encouraged Lamb to follow the same field. Lamb completed his B.Sc. in Biochemistry from University of Birmingham in 1971 followed by Ph.D. in Virology from University of Cambridge in 1974. His doctoral advisor was Brian Mahy and his thesis was about Sendai virus and explained how the virus replicates.[5]
Right after completing his Ph.D., Lamb moved to the United States and joined The Rockefeller University, New York for a postdoctoral program in virology. At The Rockefeller University, he worked with Purnell Choppin. Lamb was appointed assistant professor at The Rockefeller University in 1977, leaving the institute in 1982. In 1983, he joined Northwestern University as an associate professor where he established the Lamb Laboratory.[5]
The University of Cambridge awarded Lamb an Sc.D. in 1990 and Northwestern University appointed him the John Evans Professor of Molecular and Cellular Biology. In 1991, he joined the Howard Hughes Medical Institute as an investigator. He was appointed president of the American Society for Virology for a one-year term in 2001.[5] Lamb became Fellow of the American Association for the Advancement of Science in 1999, elected to the National Academy of Sciences in 2003 and Fellow of the American Academy of Arts and Sciences in 2007.[6] In 2010, the University of Birmingham awarded him an Sc.D. honoris causa.[7]
Lamb was appointed chair of the Department of Molecular Biosciences at Northwestern University in 2011 and served in this position until 2017. In 2016, he was appointed the Kenneth F. Burgess Professor at Northwestern University.[8]
From 1987 to 1993, Lamb was ane editor of the Journal of Virology and from 1994 to 2012, he was the editor-in-chief of Virology.[9] He served on the editorial board of Cell from 2006 to 2015. Lamb has been a member and chair of the Study Group on Paramyxoviridae, International Committee on the Taxonomy of Viruses, since 1997.[5]
While Lamb was at The Rockefeller University, he published 22 papers with Purnell Choppin. Their work mainly focused on sequencing viral genes and characterizing viral proteins. During this time, Lamb characterized the influenza A virus M2 protein, which became the focus of much of his later work.[5]
After moving to Northwestern University, Evanston, Illinois, US, Lamb set up his namesake laboratory, where he has since conducted research and collaborated with several scientists. His laboratory has studied influenza virus and paramyxoviruses, more specifically, how they replicate.[5] They have also studied the action of the M2 and BM2 proteins and enveloped virus assembly. Lamb's research has had a significant impact on the understanding of how viruses work at the molecular level through different points in the life cycle.
In 1997, Lamb and his team developed a way to stop influenza viruses from leaving their host cells, and stop the viruses at the end of their replication cycle. They found out that by disabling hemagglutinin and neuraminidase, the number of viruses exiting from the host cells decreased by 90%. Hence, they proved that hemagglutinin and neuraminidase are necessary for a complete viral replication cycle. In further research, Lamb concluded that hemagglutinin gathers at lipid rafts for an adequate concentration in the budding viruses, which results in easy entry into the next cell.[5]
In collaboration with Ted Jardetzky, Lamb determined the molecular structure of one of the pre- and post-fusion forms of the paramyxovirus fusion protein, which causes the virus membrane to fuse with the cell surface membrane. Studies on the fusion protein were applicable to the envelope proteins of SARS coronavirus, HIV and Ebola virus. All of the viral fusion proteins undergo a remarkable protein refolding event and this process brings about fusion of the viral and cellular membranes.[10]
In 1992 (for influenza A virus) and 2003 (for influenza B virus), Lamb's lab, in collaboration with Lawrence Pinto, discovered that M2 and BM2 membrane proteins of influenza A and B viruses are ion channels. Their work led to the understanding that both proteins are necessary for influenza A and B virus infection and replication.[5]
Lamb died on September 2, 2023, at the age of 72.[11]