ZNF423 explained

Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.[1] [2] [3]

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.[3] Mice lacking the homologous gene Zfp423 have defects in midline brain development, especially in the cerebellum,[4] [5] [6] as well as defects in olfactory development,[7] and adipogenesis.[8] [9] Patients with mutations in ZNF423 have been reported in Joubert Syndrome and nephronophthisis.[10]

Interactions

ZNF423 has been shown to interact with EBF1,[11] PARP1,[12] Notch intracellular domain,[13] retinoic acid receptor,[14] and CEP290.

Further reading

Notes and References

  1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 5 . 5 . 277–86 . October 1998 . 9872452 . 10.1093/dnares/5.5.277 . free .
  2. Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J . OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways . Cell . 100 . 2 . 229–40 . January 2000 . 10660046 . 10.1016/S0092-8674(00)81561-5 . 6145577 . free .
  3. Web site: Entrez Gene: ZNF423 zinc finger protein 423.
  4. Warming S, Rachel RA, Jenkins NA, Copeland NG . Zfp423 is required for normal cerebellar development . Molecular and Cellular Biology . 26 . 18 . 6913–22 . September 2006 . 16943432 . 1592861 . 10.1128/MCB.02255-05 .
  5. Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton BA . Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation . Proceedings of the National Academy of Sciences of the United States of America . 103 . 51 . 19424–9 . December 2006 . 17151198 . 1748242 . 10.1073/pnas.0609184103 . 2006PNAS..10319424A . free .
  6. Cheng LE, Zhang J, Reed RR . The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning . Developmental Biology . 307 . 1 . 43–52 . July 2007 . 17524391 . 2866529 . 10.1016/j.ydbio.2007.04.005 .
  7. Cheng LE, Reed RR . Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis . Neuron . 54 . 4 . 547–57 . May 2007 . 17521568 . 2866517 . 10.1016/j.neuron.2007.04.029 .
  8. Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM . Transcriptional control of preadipocyte determination by Zfp423 . Nature . 464 . 7288 . 619–23 . March 2010 . 20200519 . 2845731 . 10.1038/nature08816 . 2010Natur.464..619G .
  9. Shao M, Hepler C, Vishvanath L, MacPherson KA, Busbuso NC, Gupta RK . Fetal development of subcutaneous white adipose tissue is dependent on Zfp423 . Molecular Metabolism . 6 . 1 . 111–124 . January 2017 . 28123942 . 5220400 . 10.1016/j.molmet.2016.11.009 .
  10. Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton BA, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJ, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Yasunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Janssen S, Allen SJ, Natarajan S, O'Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EY, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F . 6 . Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling . Cell . 150 . 3 . 533–48 . August 2012 . 22863007 . 3433835 . 10.1016/j.cell.2012.06.028 .
  11. Tsai RY, Reed RR . Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development . The Journal of Neuroscience . 17 . 11 . 4159–69 . June 1997 . 9151733 . 10.1523/jneurosci.17-11-04159.1997. 6573535 . free .
  12. Ku MC, Stewart S, Hata A . Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes . Biochemical and Biophysical Research Communications . 311 . 3 . 702–7 . November 2003 . 14623329 . 10.1016/j.bbrc.2003.10.053 .
  13. Masserdotti G, Badaloni A, Green YS, Croci L, Barili V, Bergamini G, Vetter ML, Consalez GG . ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression . The Journal of Biological Chemistry . 285 . 40 . 30814–24 . October 2010 . 20547764 . 2945575 . 10.1074/jbc.M110.142869 . free .
  14. Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R . ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome . Cancer Cell . 15 . 4 . 328–40 . April 2009 . 19345331 . 2693316 . 10.1016/j.ccr.2009.02.023 .

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