Ro 6-3129 Explained

Ro 6-3129, also known as 16α-ethylthio-6-dehydroretroprogesterone or as 16α-ethylthio-9β,10α-pregna-4,6-diene-3,20-dione, as well as 16α-ethylthiodydrogesterone, is a progestogen of the retroprogesterone group which was developed by Roche but was never marketed.^{[1] [2] [3]} It shows greater potency than dydrogesterone in bioassays.^[4]

Notes and References

1. Book: Harper MJ . Progress in Drug Research . Contraception — retrospect and prospect . . . Jucker E . 21 . 293–407 [321] . 1977 . 339271 . 10.1007/978-3-0348-7098-6_4 . 978-3-0348-7098-6 . https://books.google.com/books?id=VFb2BwAAQBAJ&pg=PA321 .
2. Larsson-Cohn U, Johansson ED, Wide L, Gemzell C . Effects of daily administration of a retrosteroid on the plasma levels of progesterone and on the urinary excretion of luteinizing hormone and total oestrogens . The Journal of Obstetrics and Gynaecology of the British Commonwealth . 77 . 9 . 840–846 . September 1970 . 5458777 . 10.1111/j.1471-0528.1970.tb04411.x . 6176278 .
3. Dixon R, Hudson S, Darragh A . Pharmacokinetics of the retro-steroid progestogen, 16α-ethylthio-9β,10α-pregna-4, 6-diene-3, 20-dione (Ro 6-3129), in man and the sheep. Contraception. 8. 1. 1973. 53–65. 0010-7824. 10.1016/0010-7824(73)90159-5.
4. Book: The Journal of Obstetrics and Gynaecology of the British Commonwealth. 1970. Royal College of Obstetricians and Gynaecologists.