Ro 3-0422 Explained

Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous is 20 μg/kg in mice.[1] It is over 300 times more potent than neostigmine.[2]

See also

Notes and References

  1. HOBBIGER . F . The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base. . British Journal of Pharmacology and Chemotherapy . June 1954 . 9 . 2 . 159–65 . 13172424 . 1509437 . 10.1111/j.1476-5381.1954.tb00835.x.
  2. Andrews . K. J. M. . Atherton . F. R. . Bergel . F. . Morrison . A. L. . Hydroxypyridine and hydroxyquinoline phosphates as anti-cholinesterases . Journal of the Chemical Society (Resumed) . 1954 . 1638 . 10.1039/jr9540001638.

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