Ro 04-6790 Explained

Ro 04-6790 is a drug, developed by Hoffmann–La Roche, which has applications in scientific research. It acts as a potent and selective receptor antagonist for the 5-HT₆ serotonin receptor subtype, with little or no affinity at other receptors. In common with other drugs of this class,^[1] Ro 04-6790 has nootropic effects in animals,^[2] and reduces the amnesia produced by memory-impairing drugs such as dizocilpine^[3] and scopolamine.^[4]

Notes and References

1. Fone KC . An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function . Neuropharmacology . 55 . 6 . 1015–22 . November 2008 . 18655798 . 10.1016/j.neuropharm.2008.06.061 . 35522597 .
2. King MV, Spicer CH, Sleight AJ, Marsden CA, Fone KC . Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht(6) receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task . Psychopharmacology . 202 . 1–3 . 111–23 . January 2009 . 18839151 . 10.1007/s00213-008-1334-1 . 10826081 .
3. Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N . The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801 . Behavioural Brain Research . 188 . 2 . 304–9 . April 2008 . 18164078 . 10.1016/j.bbr.2007.11.010 . 40183481 .
4. Woolley ML, Marsden CA, Sleight AJ, Fone KC . Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790 . Psychopharmacology . 170 . 4 . 358–67 . December 2003 . 13680084 . 10.1007/s00213-003-1552-5 . 25193679 .