Rnd1 Explained

Rnd1 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.^[1] It is encoded by the gene RND1.^[2]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM]

Interactions

Rnd1 has been shown to interact with GRB7,^[3] PLXNB1,^[4] PDE6D,^{[5] [6]} ARHGAP5^[7] and UBXD5.^[8]

Further reading

• Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P . A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion . The Journal of Cell Biology . 141 . 1 . 187–97 . Apr 1998 . 9531558 . 2132722 . 10.1083/jcb.141.1.187 .
• Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J . Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family . FEBS Letters . 467 . 1 . 91–6 . Feb 2000 . 10664463 . 10.1016/S0014-5793(99)01530-6 . 4901644 . free .
• Aoki J, Katoh H, Mori K, Negishi M . Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells . Biochemical and Biophysical Research Communications . 278 . 3 . 604–8 . Nov 2000 . 11095956 . 10.1006/bbrc.2000.3842 .
• Rohm B, Rahim B, Kleiber B, Hovatta I, Püschel AW . The semaphorin 3A receptor may directly regulate the activity of small GTPases . FEBS Letters . 486 . 1 . 68–72 . Dec 2000 . 11108845 . 10.1016/S0014-5793(00)02240-7 . 7914214 . free .
• Nancy V, Callebaut I, El Marjou A, de Gunzburg J . The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases . The Journal of Biological Chemistry . 277 . 17 . 15076–84 . Apr 2002 . 11786539 . 10.1074/jbc.M109983200 . free .
• Katoh H, Harada A, Mori K, Negishi M . Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers . Molecular and Cellular Biology . 22 . 9 . 2952–64 . May 2002 . 11940653 . 133765 . 10.1128/MCB.22.9.2952-2964.2002 .
• Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC . The complex of Arl2-GTP and PDE delta: from structure to function . The EMBO Journal . 21 . 9 . 2095–106 . May 2002 . 11980706 . 125981 . 10.1093/emboj/21.9.2095 .
• Oinuma I, Katoh H, Harada A, Negishi M . Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells . The Journal of Biological Chemistry . 278 . 28 . 25671–7 . Jul 2003 . 12730235 . 10.1074/jbc.M303047200 . free .
• Oinuma I, Ishikawa Y, Katoh H, Negishi M . The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras . Science . 305 . 5685 . 862–5 . Aug 2004 . 15297673 . 10.1126/science.1097545 . 2004Sci...305..862O . 39544623 .
• Harada A, Katoh H, Negishi M . Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells . The Journal of Biological Chemistry . 280 . 18 . 18418–24 . May 2005 . 15738000 . 10.1074/jbc.M411356200 . free .
• Kim YS, Hori M, Yasuda K, Ozaki H . Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria . Comparative Biochemistry and Physiology A . 142 . 4 . 410–5 . Dec 2005 . 16311049 . 10.1016/j.cbpa.2005.08.028 .

Notes and References

1. Ridley AJ . Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking . Trends in Cell Biology . 16 . 10 . 522–9 . Oct 2006 . 16949823 . 10.1016/j.tcb.2006.08.006 .
2. Web site: Entrez Gene: RND1 Rho family GTPase 1.
3. Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J . Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family . FEBS Letters . 467 . 1 . 91–6 . Feb 2000 . 10664463 . 10.1016/S0014-5793(99)01530-6 . 4901644 . free .
4. Oinuma I, Katoh H, Harada A, Negishi M . Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells . The Journal of Biological Chemistry . 278 . 28 . 25671–7 . Jul 2003 . 12730235 . 10.1074/jbc.M303047200 . free .
5. Nancy V, Callebaut I, El Marjou A, de Gunzburg J . The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases . The Journal of Biological Chemistry . 277 . 17 . 15076–84 . Apr 2002 . 11786539 . 10.1074/jbc.M109983200 . free .
6. Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC . The complex of Arl2-GTP and PDE delta: from structure to function . The EMBO Journal . 21 . 9 . 2095–106 . May 2002 . 11980706 . 125981 . 10.1093/emboj/21.9.2095 .
7. Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH . Rnd proteins function as RhoA antagonists by activating p190 RhoGAP . Current Biology . 13 . 13 . 1106–15 . Jul 2003 . 12842009 . 10.1016/S0960-9822(03)00418-4 . 6918695 . 2003CBio...13.1106W .
8. Katoh H, Harada A, Mori K, Negishi M . Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers . Molecular and Cellular Biology . 22 . 9 . 2952–64 . May 2002 . 11940653 . 133765 . 10.1128/MCB.22.9.2952-2964.2002 .