| Dene | |
| Subdivision Type1: | Country |
| Subdivision Name1: | England |
| Subdivision Type3: | County |
| Subdivision Name3: | Warwickshire |
| Source1 Location: | Burton Dassett Hills |
| Mouth: | Avon |
| Mouth Location: | Charlecote Park |
| Mouth Coordinates: | 52.2044°N -1.6231°W |
The River Dene is a small river in Warwickshire, England.
It is a tributary of the Avon, which it joins at Charlecote Park. The headwaters of the River Dene rise on the western slopes of the Burton Dassett Hills and flow westward towards Kineton. Five miles downstream of Kineton, the river turns abruptly north, flowing through the villages of Walton and Wellesbourne before joining the Avon.
To the west of Kineton, the Dene was followed, and bridged in numerous places, by the Stratford-upon-Avon and Midland Junction Railway. At Kineton can be seen the remains of four sets of sluice-gates, possibly used for flooding the land in the cultivation of osiers for use in basket making.