Ringer's solution explained

Ringer's solution is a solution of several salts dissolved in water for the purpose of creating an isotonic solution relative to the body fluids of an animal. Ringer's solution typically contains sodium chloride, potassium chloride, calcium chloride and sodium bicarbonate, with the last used to balance the pH. Other additions can include chemical fuel sources for cells, including ATP and dextrose, as well as antibiotics and antifungals.

Composition

Ringer's solution typically contains NaCl, KCl, CaCl2 and NaHCO3, sometimes with other minerals such as MgCl2, dissolved in distilled water. The precise proportions of these vary from species to species, particularly between marine osmoconformers and osmoregulators.[1] [2]

Uses

Ringer's solution is frequently administered to human and veterinary patients for intravenous or subcutaneous hydration and to expand the vascular compartment in hypovolemia. It is also use in in vitro experiments on organs or tissues, such as in vitro muscle testing.[3] [4] [5] [6] The precise mix of ions can vary depending upon the taxon, with different recipes for birds, mammals, freshwater fish, marine fish, etc.

Ringers solution may also be used for therapeutic purposes, such as arthroscopic lavage in the case of septic arthritis.[7] [8] It is used clinically as an intravenous infusion for replacing extracellular fluid losses and restoring chemical balances when treating isotonic dehydration.[9]

History

Ringer's solution is named after Sydney Ringer, who in 1882–1885 determined that a solution perfusing a frog's heart must contain sodium, potassium and calcium salts in a definite proportion if the heart is to be kept beating for long.[10] [11] This solution was adjusted further in the 1930s by Alexis Hartmann, who added sodium lactate to form Ringer's lactate solution.[12]

References

  1. Web site: COMPENDIA NOTES, PART B: RINGER'S SOLUTIONS . Marine Biological Laboratory . 10 June 2018.
  2. Web site: Table 3. Composition of Ringer's Solution . Research Gate . 10 June 2018.
  3. Web site: What is Ringer's solution? . HydroTherapy . 10 June 2018.
  4. Titanium–magnesium based composites: Mechanical properties and in-vitro corrosion response in Ringer's solution . Materials Science and Engineering: A . 20 Jun 2013 . 573 . 119–126 . 10.1016/j.msea.2013.02.040 . Esen . Ziya . Dikici . Burak . Duygulu . Ozgur . Dericioglu . Arcan F. .
  5. Effect of Plasma-Activated Lactated Ringer's Solution on Pancreatic Cancer Cells In Vitro and In Vivo . Annals of Surgical Oncology . Jan 2018 . 25 . 1 . 299–307 . 10.1245/s10434-017-6239-y . 29139022 . Sato . Yusuke . Yamada . Suguru . Takeda . Shigeomi . Hattori . Norifumi . Nakamura . Kae . Tanaka . Hiromasa . Mizuno . Masaaki . Hori . Masaru . Kodera . Yasuhiro . 118485 .
  6. Retaining ionic concentrations during in vitro storage of tissue for microanalytical studies . Journal of Microscopy . 3 Mar 1999 . 193 . 3 . 257–267 . 10.1046/j.1365-2818.1999.00461.x . Hongpaisan . J. . Roomans . G. M. . 10199004 . 20969681 .
  7. Clinical Management of Septic Arthritis in a Sheep: A Case Report . Advances in Animal and Veterinary Sciences . July 2017 . 5 . 6 . 267–270 .
  8. Effect of irrigation solutions for arthroscopic surgery on intraarticular tissue: comparison in human meniscus-derived primary cell culture between lactate Ringer's solution and saline solution . Journal of Orthopaedic Research . 2002 . 20 . 6 . 1305–1310 . 10.1016/S0736-0266(02)00062-1 . 12472244 . Shinjo . Hirotaka . Nakata . Ken . Shino . Konsei . Hamada . Masayuki . Nakamura . Norimasa . Mae . Tatsuo . Miyama . Takahide . Horibe . Shuji . Yoshikawa . Hideki . Ochi . Takahiro . free .
  9. Web site: Ringers Solution for Infusion . Electronic Medicines Compendium . 10 June 2018.
  10. Book: Hille, Bertil. Ionic Channels of Excitable Membranes. 1984. Sinauer Associates, Inc.. Sunderland, Mass. 01375. 978-0-87893-322-8.
  11. 14742734. 1664856. 2004. Miller. David J.. Sydney Ringer; physiological saline, calcium and the contraction of the heart. 555. 3. 585–587. 10.1113/jphysiol.2004.060731. The Journal of Physiology.
  12. Book: Marino. Paul L.. Sutin. Kenneth M.. The ICU Book. 2012. Lippincott Williams & Wilkins. 9781451161557. 363. 3. en.

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