Riligustilide Explained

Riligustilide is a nonsteroidal phytoprogestogen that is found in Ligusticum chuanxiong.^{[1] [2]} It is a very weak agonist of the progesterone receptor (EC₅₀ ≈ 81 μM). Another compound in the plant, 3,8-dihydrodiligustilide, is also a phytoprogestogen, but is almost 1,000-fold more potent in comparison (EC₅₀ = 90 nM).

See also

• Kaempferol
• Tanaproget

Notes and References

1. Lim LS, Shen P, Gong YH, Yong EL . Dimeric progestins from rhizomes of Ligusticum chuanxiong . Phytochemistry . 67 . 7 . 728–34 . 2006 . 16516938 . 10.1016/j.phytochem.2006.01.024 .
2. Ahmed. H.M.M.. Yeh. J.Y.. Lin. W.J.. Forsberg. N.E.. Cheng. W.T.K.. Ou. B.R. Validation of a luciferase bioassay to detect the progestative activity in gilts whose estrus was induced by an uterotonic herb (Ligusticum chuanxiong). Livestock Science. 163. 2014. 159–164. 1871-1413. 10.1016/j.livsci.2014.02.012.